METHODS: We will conduct a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials (RCTs) assessing the patient-important effects of selective decontamination of the digestive tract in burn patients, as compared with placebo or no intervention/standard of care. The primary outcome will be 30-day mortality. Secondary outcomes include serious adverse events, anti-microbial resistance, pneumonia, blood stream infections, ICU- and hospital-free days and 90-day mortality. We will search the following databases: CENTRAL, MEDLINE, EMBASE, BIOSIS, Web of Science and CINAHL and follow the recommendations provided by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The certainty of evidence will be assessed according to the GRADE approach: Grading of Recommendations Assessment, Development and Evaluation.
CONCLUSIONS: There is clinical equipoise about the use of selective decontamination of the digestive tract in burn patients. In the outlined systematic review and meta-analysis, we will assess the desirable and undesirable effects of selective decontamination of the digestive tract in burn patients.
方法:我们将对随机临床试验(RCTs)进行荟萃分析和试验序贯分析,以评估烧伤患者消化道选择性去污的患者重要影响,与安慰剂或无干预/标准护理相比。主要结果是30天死亡率。次要结果包括严重不良事件,抗微生物抗性,肺炎,血流感染,无ICU和无医院天数和90天死亡率。我们将搜索以下数据库:CENTRAL,MEDLINE,EMBASE,BIOSIS,WebofScience和CINAHL,并遵循Cochrane合作组织提供的建议以及系统评价和荟萃分析指南的首选报告项目。证据的确定性将根据分级方法进行评估:建议评估的分级,发展和评价。
结论:在烧伤患者中使用消化道选择性去污具有临床一致性。在概述的系统综述和荟萃分析中,我们将评估烧伤患者消化道选择性净化的理想和不良效果。