Abstract：
BACKGROUND: Nosocomial infections contribute significantly to mortality and morbidity in burn patients. Selective decontamination of the digestive tract is an infection prevention measure that has been shown to improve survival in mechanically ventilated intensive care unit (ICU) patients. It has been hypothesized that burn patients may benefit from selective decontamination of the digestive tract.
METHODS: We will conduct a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials (RCTs) assessing the patient-important effects of selective decontamination of the digestive tract in burn patients, as compared with placebo or no intervention/standard of care. The primary outcome will be 30-day mortality. Secondary outcomes include serious adverse events, anti-microbial resistance, pneumonia, blood stream infections, ICU- and hospital-free days and 90-day mortality. We will search the following databases: CENTRAL, MEDLINE, EMBASE, BIOSIS, Web of Science and CINAHL and follow the recommendations provided by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The certainty of evidence will be assessed according to the GRADE approach: Grading of Recommendations Assessment, Development and Evaluation.
CONCLUSIONS: There is clinical equipoise about the use of selective decontamination of the digestive tract in burn patients. In the outlined systematic review and meta-analysis, we will assess the desirable and undesirable effects of selective decontamination of the digestive tract in burn patients.
METHODS: We will conduct a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials (RCTs) assessing the patient-important effects of selective decontamination of the digestive tract in burn patients, as compared with placebo or no intervention/standard of care. The primary outcome will be 30-day mortality. Secondary outcomes include serious adverse events, anti-microbial resistance, pneumonia, blood stream infections, ICU- and hospital-free days and 90-day mortality. We will search the following databases: CENTRAL, MEDLINE, EMBASE, BIOSIS, Web of Science and CINAHL and follow the recommendations provided by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The certainty of evidence will be assessed according to the GRADE approach: Grading of Recommendations Assessment, Development and Evaluation.
CONCLUSIONS: There is clinical equipoise about the use of selective decontamination of the digestive tract in burn patients. In the outlined systematic review and meta-analysis, we will assess the desirable and undesirable effects of selective decontamination of the digestive tract in burn patients.
摘要：
背景：医院感染对烧伤患者的死亡率和发病率有显著影响。消化道的选择性净化是一种预防感染的措施，已被证明可以提高机械通气的重症监护病房（ICU）患者的生存率。据推测，烧伤患者可能会受益于消化道的选择性净化。
方法：我们将对随机临床试验（RCTs）进行荟萃分析和试验序贯分析，以评估烧伤患者消化道选择性去污的患者重要影响，与安慰剂或无干预/标准护理相比。主要结果是30天死亡率。次要结果包括严重不良事件，抗微生物抗性，肺炎,血流感染,无ICU和无医院天数和90天死亡率。我们将搜索以下数据库：CENTRAL,MEDLINE,EMBASE,BIOSIS,WebofScience和CINAHL，并遵循Cochrane合作组织提供的建议以及系统评价和荟萃分析指南的首选报告项目。证据的确定性将根据分级方法进行评估：建议评估的分级，发展和评价。
结论：在烧伤患者中使用消化道选择性去污具有临床一致性。在概述的系统综述和荟萃分析中，我们将评估烧伤患者消化道选择性净化的理想和不良效果。
方法：我们将对随机临床试验（RCTs）进行荟萃分析和试验序贯分析，以评估烧伤患者消化道选择性去污的患者重要影响，与安慰剂或无干预/标准护理相比。主要结果是30天死亡率。次要结果包括严重不良事件，抗微生物抗性，肺炎,血流感染,无ICU和无医院天数和90天死亡率。我们将搜索以下数据库：CENTRAL,MEDLINE,EMBASE,BIOSIS,WebofScience和CINAHL，并遵循Cochrane合作组织提供的建议以及系统评价和荟萃分析指南的首选报告项目。证据的确定性将根据分级方法进行评估：建议评估的分级，发展和评价。
结论：在烧伤患者中使用消化道选择性去污具有临床一致性。在概述的系统综述和荟萃分析中，我们将评估烧伤患者消化道选择性净化的理想和不良效果。
