PDF(Pubmed)
Abstract：
In order to assess homeostatic mechanisms in the lung after COVID-19, changes in the protein signature of bronchoalveolar lavage from 45 patients with mild to moderate disease at three phases (acute, recovery, and convalescent) are evaluated over a year. During the acute phase, inflamed and uninflamed phenotypes are characterized by the expression of tissue repair and host defense response molecules. With recovery, inflammatory and fibrogenic mediators decline and clinical symptoms abate. However, at 9 months, quantified radiographic abnormalities resolve in the majority of patients, and yet compared to healthy persons, all showed ongoing activation of cellular repair processes and depression of the renin-kallikrein-kinin, coagulation, and complement systems. This dissociation of prolonged reparative processes from symptom and radiographic resolution suggests that occult ongoing disruption of the lung proteome is underrecognized and may be relevant to recovery from other serious viral pneumonias.
摘要：
为了评估COVID-19后肺的稳态机制，45例轻度至中度疾病患者在三个阶段（急性，recovery,和恢复期）在一年内进行评估。在急性期,发炎和未发炎表型的特征在于组织修复和宿主防御反应分子的表达。随着恢复，炎症和纤维化介质下降，临床症状减轻。然而,9个月时,量化的放射学异常在大多数患者中解决，然而与健康人相比，所有显示细胞修复过程的持续激活和肾素-激肽释放酶-激肽的抑制，凝血,补充系统。这种延长的修复过程与症状和放射学分辨率的分离表明，肺蛋白质组的隐匿性持续破坏未被认识到，并且可能与其他严重的病毒性肺炎的恢复有关。
