Abstract：
Cancer is a multifaceted disease driven by abnormal cell growth and poses a significant global health threat. The multifactorial causes, differences in individual susceptibility to therapeutic drugs, and induced drug resistance pose major challenges in addressing cancers effectively. One of the most important aspects in making cancers highly heterogeneous in their physiology lies in the genes involved and the changes occurring to some of these genes in malignant conditions. The Genetic factors have been implicated in the oncogenesis, progression, responses to treatment, and metastasis. One such gene that plays a key role in human cancers is the mutated form of the Ataxia-telangiectasia gene (ATM). ATM gene located on chromosome 11q23, plays a vital role in maintaining genomic stability. Understanding the genetic basis of A-T is crucial for diagnosis, management, and treatment. Breast cancer, lung cancer, prostate cancer, and gastric cancer exhibit varying relationships with the ATM gene and influence their pathways. Targeting the ATM pathway proves promising for enhancing treatment effectiveness, especially in conjunction with DNA damage response pathways. Analyzing the therapeutic consequences of ATM mutations, especially in these cancer types facilitates the approaches for early detection, intervention, development of personalized treatment approaches, and improved patient outcomes. This review emphasizes the role of the ATM gene in various cancers, highlighting its impact on DNA repair pathways and therapeutic responses.
摘要：
癌症是一种由异常细胞生长驱动的多层面疾病，对全球健康构成重大威胁。多因素原因，个体对治疗药物敏感性的差异，和诱导的耐药性在有效解决癌症方面构成了重大挑战。使癌症在其生理上高度异质性的最重要方面之一在于所涉及的基因以及在恶性状况下这些基因中的一些发生的变化。遗传因素与肿瘤发生有关，programming,对治疗的反应，和转移。在人类癌症中起关键作用的一种这样的基因是共济失调-毛细血管扩张基因(ATM)的突变形式。ATM基因位于染色体11q23上，在维持基因组稳定性方面起着至关重要的作用。了解A-T的遗传基础对诊断至关重要，管理,和治疗。乳腺癌,肺癌,前列腺癌,和胃癌表现出与ATM基因的不同关系并影响其通路。针对ATM途径证明有希望提高治疗效果，特别是与DNA损伤反应途径有关。分析ATM突变的治疗后果，特别是在这些癌症类型中，促进了早期检测的方法，干预，个性化治疗方法的发展，改善患者预后。这篇综述强调了ATM基因在各种癌症中的作用。强调其对DNA修复途径和治疗反应的影响。
