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Abstract：
BACKGROUND: Benign prostatic hyperplasia (BPH) is a common health disorder of the male genitourinary system with a high prevalence, especially among middle-aged and older adults, which seriously affects men\'s quality of life. Inflammatory markers derived from complete blood cell count (CBC) have previously been considered a prognostic indicator for various diseases, but little is known about their relationship with BPH. This study evaluated the relationship between complete blood cell count (CBC)-derived inflammatory biomarkers and BPH.
METHODS: Data for this cross-sectional study were gathered from the National Health and Nutrition Examination Survey (NHANES) between 2001 and 2008. Using multiple logistic regressions, the study examined the association between benign prostatic hyperplasia(BPH) and Inflammatory biomarkers derived from blood cell counts such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), Systemic Inflammatory Response Index (SIRI) and Systemic Immunoinflammatory Index (SII).
RESULTS: 3,919 participants were included, with a median age of 61.00 (52.00-71.00) years old. Among them, 609 participants had benign prostatic hyperplasia, with a prevalence of 15.54%. Upon accounting for confounding factors, the study revealed a positive correlation between the plurality of BPH PLR and SII. However, MLR, NLR, and SIRI did not significantly correlate with the prevalence of BPH (p>0.05). In contrast to the lowest quartile, higher quartiles of PLR (OR = 1.93[1.38-2.69]) and SII (OR = 1.71[1.22-2.40]) were linked to an elevated risk of BPH. Interaction tests showed that age, body mass index, hypertension, diabetes, smoking, and drinking had no significant effect on this positive correlation (p for interaction>0.05). In addition, we found a roughly linear association between SII, PLR, and BPH using smoothed curve fitting.
CONCLUSIONS: According to our research, high levels of PLR and SII are positively linked with an increased risk of BPH in middle-aged and elderly individuals in the United States. The results compensate for previous studies that still need to be validated with larger prospective cohorts.
METHODS: Data for this cross-sectional study were gathered from the National Health and Nutrition Examination Survey (NHANES) between 2001 and 2008. Using multiple logistic regressions, the study examined the association between benign prostatic hyperplasia(BPH) and Inflammatory biomarkers derived from blood cell counts such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), Systemic Inflammatory Response Index (SIRI) and Systemic Immunoinflammatory Index (SII).
RESULTS: 3,919 participants were included, with a median age of 61.00 (52.00-71.00) years old. Among them, 609 participants had benign prostatic hyperplasia, with a prevalence of 15.54%. Upon accounting for confounding factors, the study revealed a positive correlation between the plurality of BPH PLR and SII. However, MLR, NLR, and SIRI did not significantly correlate with the prevalence of BPH (p>0.05). In contrast to the lowest quartile, higher quartiles of PLR (OR = 1.93[1.38-2.69]) and SII (OR = 1.71[1.22-2.40]) were linked to an elevated risk of BPH. Interaction tests showed that age, body mass index, hypertension, diabetes, smoking, and drinking had no significant effect on this positive correlation (p for interaction>0.05). In addition, we found a roughly linear association between SII, PLR, and BPH using smoothed curve fitting.
CONCLUSIONS: According to our research, high levels of PLR and SII are positively linked with an increased risk of BPH in middle-aged and elderly individuals in the United States. The results compensate for previous studies that still need to be validated with larger prospective cohorts.
摘要：
背景：良性前列腺增生（BPH）是男性泌尿生殖系统的常见健康疾病，患病率很高，尤其是中老年人，严重影响男性的生活质量。来自全血细胞计数（CBC）的炎症标志物以前被认为是各种疾病的预后指标。但对他们与BPH的关系知之甚少。这项研究评估了全血细胞计数（CBC）衍生的炎症生物标志物与BPH之间的关系。
方法：这项横断面研究的数据来自2001年至2008年的国家健康和营养调查（NHANES）。使用多重逻辑回归，该研究检查了良性前列腺增生（BPH）与来自血细胞计数的炎症生物标志物之间的关联，例如中性粒细胞与淋巴细胞比率（NLR），血小板与淋巴细胞比率（PLR），单核细胞与淋巴细胞比率（MLR），全身炎症反应指数(SIRI)和全身免疫炎症指数(SII)。
结果：纳入3,919名参与者，年龄中位数为61.00（52.00-71.00）岁。其中,609名参与者患有良性前列腺增生，患病率为15.54%。在考虑混杂因素时，该研究揭示了多个BPHPLR和SII之间的正相关。然而,MLR,NLR,SIRI与BPH的患病率无显著相关性(p>0.05)。与最低四分位数相反，PLR(OR=1.93[1.38-2.69])和SII(OR=1.71[1.22-2.40])的四分位数较高与BPH风险升高相关.相互作用测试表明，年龄，身体质量指数,高血压,糖尿病,吸烟,饮酒对这种正相关无显著影响(p>0.05)。此外,我们发现SII之间大致呈线性关系，PLR,和BPH使用平滑曲线拟合。
结论：根据我们的研究，在美国，高水平的PLR和SII与中老年人BPH风险增加呈正相关。该结果弥补了以前的研究，这些研究仍需要用更大的前瞻性队列进行验证。
方法：这项横断面研究的数据来自2001年至2008年的国家健康和营养调查（NHANES）。使用多重逻辑回归，该研究检查了良性前列腺增生（BPH）与来自血细胞计数的炎症生物标志物之间的关联，例如中性粒细胞与淋巴细胞比率（NLR），血小板与淋巴细胞比率（PLR），单核细胞与淋巴细胞比率（MLR），全身炎症反应指数(SIRI)和全身免疫炎症指数(SII)。
结果：纳入3,919名参与者，年龄中位数为61.00（52.00-71.00）岁。其中,609名参与者患有良性前列腺增生，患病率为15.54%。在考虑混杂因素时，该研究揭示了多个BPHPLR和SII之间的正相关。然而,MLR,NLR,SIRI与BPH的患病率无显著相关性(p>0.05)。与最低四分位数相反，PLR(OR=1.93[1.38-2.69])和SII(OR=1.71[1.22-2.40])的四分位数较高与BPH风险升高相关.相互作用测试表明，年龄，身体质量指数,高血压,糖尿病,吸烟,饮酒对这种正相关无显著影响(p>0.05)。此外,我们发现SII之间大致呈线性关系，PLR,和BPH使用平滑曲线拟合。
结论：根据我们的研究，在美国，高水平的PLR和SII与中老年人BPH风险增加呈正相关。该结果弥补了以前的研究，这些研究仍需要用更大的前瞻性队列进行验证。
