Abstract：
BACKGROUND: This study aimed at describing the epidemiology of (neuro)cysticercosis as well as its clinical and radiological characteristics in a Taenia solium endemic district of Zambia.
METHODS: This was part of a cross-sectional community-based study conducted in Sinda district to evaluate an antibody-detecting T. solium point-of-care (TS POC) test for taeniosis and (neuro)cysticercosis. All TS POC cysticercosis positive (CC+) participants and a subset of the TS POC cysticercosis negative (CC-) received a clinical evaluation and cerebral computed tomography (CT) examination for neurocysticercosis (NCC) diagnosis and staging.
RESULTS: Of the 1249 participants with a valid TS POC test result, 177 (14%) were TS POC CC+ . Cysticercosis sero-prevalence was estimated to be 20.1% (95% confidence intervals [CI] 14.6-27.0%). In total, 233 participants received a CT examination (151 TS POC CC+ , 82 TS POC CC-). Typical NCC lesions were present in 35/151 (23%) TS POC CC+ , and in 10/82 (12%) TS POC CC- participants. NCC prevalence was 13.5% (95% CI 8.4-21.1%) in the study population and 38.0% (95% CI 5.2-87.4%) among people reporting epileptic seizures. Participants with NCC were more likely to experience epileptic seizures (OR = 3.98, 95% CI 1.34-11.78, p = 0.01) than those without NCC, although only 7/45 (16%) people with NCC ever experienced epileptic seizures. The number of lesions did not differ by TS POC CC status (median: 3 [IQR 1-6] versus 2.5 [IQR 1-5.3], p = 0.64). Eight (23%) of the 35 TS POC CC+ participants with NCC had active stage lesions; in contrast none of the TS POC CC- participants was diagnosed with active NCC.
CONCLUSIONS: NCC is common in communities in the Eastern province of Zambia, but a large proportion of people remain asymptomatic.
METHODS: This was part of a cross-sectional community-based study conducted in Sinda district to evaluate an antibody-detecting T. solium point-of-care (TS POC) test for taeniosis and (neuro)cysticercosis. All TS POC cysticercosis positive (CC+) participants and a subset of the TS POC cysticercosis negative (CC-) received a clinical evaluation and cerebral computed tomography (CT) examination for neurocysticercosis (NCC) diagnosis and staging.
RESULTS: Of the 1249 participants with a valid TS POC test result, 177 (14%) were TS POC CC+ . Cysticercosis sero-prevalence was estimated to be 20.1% (95% confidence intervals [CI] 14.6-27.0%). In total, 233 participants received a CT examination (151 TS POC CC+ , 82 TS POC CC-). Typical NCC lesions were present in 35/151 (23%) TS POC CC+ , and in 10/82 (12%) TS POC CC- participants. NCC prevalence was 13.5% (95% CI 8.4-21.1%) in the study population and 38.0% (95% CI 5.2-87.4%) among people reporting epileptic seizures. Participants with NCC were more likely to experience epileptic seizures (OR = 3.98, 95% CI 1.34-11.78, p = 0.01) than those without NCC, although only 7/45 (16%) people with NCC ever experienced epileptic seizures. The number of lesions did not differ by TS POC CC status (median: 3 [IQR 1-6] versus 2.5 [IQR 1-5.3], p = 0.64). Eight (23%) of the 35 TS POC CC+ participants with NCC had active stage lesions; in contrast none of the TS POC CC- participants was diagnosed with active NCC.
CONCLUSIONS: NCC is common in communities in the Eastern province of Zambia, but a large proportion of people remain asymptomatic.
摘要：
背景：本研究旨在描述赞比亚猪带虫流行区（神经）囊虫病的流行病学及其临床和放射学特征。
方法：这是一项在信达地区进行的基于社区的横断面研究的一部分，该研究旨在评估抗体检测T.solium即时护理（TSPOC）测试的taeniosis和（神经）囊虫病。所有TSPOC囊虫病阳性（CC）参与者和TSPOC囊虫病阴性（CC-）的一部分接受了临床评估和脑计算机断层扫描（CT）检查，以进行神经囊虫病（NCC）的诊断和分期。
结果：在具有有效TSPOC测试结果的1249名参与者中，177(14%)为TSPOCCC+。囊虫病血清患病率估计为20.1％（95％置信区间[CI]14.6-27.0％）。总的来说,233名参与者接受了CT检查(151TSPOCCC+，82TSPOCCC-）。典型的NCC病变出现在35/151（23%）TSPOCCC+中，和10/82（12%）TSPOCCC参与者。研究人群的NCC患病率为13.5％（95％CI8.4-21.1％），报告癫痫发作的人群为38.0％（95％CI5.2-87.4％）。有NCC的参与者比没有NCC的参与者更有可能出现癫痫发作（OR=3.98，95％CI1.34-11.78，p=0.01）。尽管只有7/45（16％）的NCC患者经历过癫痫发作。病变数量因TSPOCCC状态而无差异（中位数：3[IQR1-6]对2.5[IQR1-5.3]，p=0.64）。35名具有NCC的TSPOCCC+参与者中有8名（23％）具有活跃期病变；相比之下，TSPOCCC-参与者均未被诊断为活跃的NCC。
结论：NCC在赞比亚东部省的社区中很常见，但是很大一部分人仍然无症状。
方法：这是一项在信达地区进行的基于社区的横断面研究的一部分，该研究旨在评估抗体检测T.solium即时护理（TSPOC）测试的taeniosis和（神经）囊虫病。所有TSPOC囊虫病阳性（CC）参与者和TSPOC囊虫病阴性（CC-）的一部分接受了临床评估和脑计算机断层扫描（CT）检查，以进行神经囊虫病（NCC）的诊断和分期。
结果：在具有有效TSPOC测试结果的1249名参与者中，177(14%)为TSPOCCC+。囊虫病血清患病率估计为20.1％（95％置信区间[CI]14.6-27.0％）。总的来说,233名参与者接受了CT检查(151TSPOCCC+，82TSPOCCC-）。典型的NCC病变出现在35/151（23%）TSPOCCC+中，和10/82（12%）TSPOCCC参与者。研究人群的NCC患病率为13.5％（95％CI8.4-21.1％），报告癫痫发作的人群为38.0％（95％CI5.2-87.4％）。有NCC的参与者比没有NCC的参与者更有可能出现癫痫发作（OR=3.98，95％CI1.34-11.78，p=0.01）。尽管只有7/45（16％）的NCC患者经历过癫痫发作。病变数量因TSPOCCC状态而无差异（中位数：3[IQR1-6]对2.5[IQR1-5.3]，p=0.64）。35名具有NCC的TSPOCCC+参与者中有8名（23％）具有活跃期病变；相比之下，TSPOCCC-参与者均未被诊断为活跃的NCC。
结论：NCC在赞比亚东部省的社区中很常见，但是很大一部分人仍然无症状。
