Abstract：
Ferroptosis is a programmed cell death that relies on iron and lipid peroxidation. It differs from other forms of programmed cell death such as necrosis, apoptosis and autophagy. More and more evidence indicates that ferroptosis participates in many types of diseases, such as neurodegenerative diseases, ischemia-reperfusion injury, cardiovascular diseases and so on. Hence, clarifying the role and mechanism of ferroptosis in diseases is of great significance for further understanding the pathogenesis and treatment of some diseases. Hydrogen sulfide (H2S) is a colorless and flammable gas with the smell of rotten eggs. Many years ago, H2S was considered as a toxic gas. however, in recent years, increasing evidence indicates that it is the third important gas signaling molecule after nitric oxide and carbon monoxide. H2S has various physiological and pathological functions such as antioxidant stress, anti-inflammatory, anti-apoptotic and anti-tumor, and can participate in various diseases. It has been reported that H2S regulation of ferroptosis plays an important role in many types of diseases, however, the related mechanisms are not fully clear. In this review, we reviewed the recent literature about the role of H2S regulation of ferroptosis in diseases, and analyzed the relevant mechanisms, hoping to provide references for future in-depth researches.
摘要：
铁凋亡是依赖于铁和脂质过氧化的程序性细胞死亡。它不同于其他形式的程序性细胞死亡，如坏死，细胞凋亡和自噬。越来越多的证据表明铁性凋亡参与多种疾病的发生,如神经退行性疾病，缺血再灌注损伤,心血管疾病等。因此，阐明铁性凋亡在疾病中的作用和机制,对于进一步了解某些疾病的发病机制和治疗具有重要意义。硫化氢（H2S）是一种无色易燃的气体，有臭鸡蛋的气味。很多年前,H2S被认为是有毒气体。然而,近年来,越来越多的证据表明，它是继一氧化氮和一氧化碳之后的第三个重要的气体信号分子。H2S具有抗氧化应激等多种生理和病理功能,抗炎,抗凋亡和抗肿瘤，可以参与各种疾病。据报道,H2S对铁凋亡的调控在多种疾病中起着重要作用,然而,相关机制尚不完全清楚。在这次审查中,我们回顾了近年来有关H2S调节铁性凋亡在疾病中的作用的文献,并分析了相关机制，希望为今后的深入研究提供参考。
