Abstract：
The circulation of tumor cells through the bloodstream is a significant step in tumor metastasis. To better understand the metastatic process, circulating tumor cell (CTC) survival in the circulation must be explored. While immune interactions with CTCs in recent decades have been examined, research has yet to sufficiently explain some CTC behaviors in blood flow. Studies related to CTC mechanical responses in the bloodstream have recently been conducted to further study conditions under which CTCs might die. While experimental methods can assess the mechanical properties and death of CTCs, increasingly sophisticated computational models are being built to simulate the blood flow and CTC mechanical deformation under fluid shear stresses (FSS) in the bloodstream.Several factors contribute to the mechanical deformation and death of CTCs as they circulate. While FSS can damage CTC structure, diverse interactions between CTCs and blood components may either promote or hinder the next metastatic step-extravasation at a remote site. Overall understanding of how these factors influence the deformation and death of CTCs could serve as a basis for future experiments and simulations, enabling researchers to predict CTC death more accurately. Ultimately, these efforts can lead to improved metastasis-specific therapeutics and diagnostics specific in the future.
摘要：
肿瘤细胞通过血流的循环是肿瘤转移的重要步骤。为了更好地理解转移过程，必须探索循环肿瘤细胞（CTC）在循环中的存活。虽然近几十年来与CTC的免疫相互作用已经被检查，研究尚未充分解释血流中的某些CTC行为。最近进行了与血液中的CTC机械响应有关的研究，以进一步研究CTC可能死亡的条件。虽然实验方法可以评估CTC的机械性能和死亡，正在建立越来越复杂的计算模型来模拟血流中流体剪切应力（FSS）下的血流和CTC机械变形。几个因素导致CTC循环时的机械变形和死亡。虽然FSS会损坏CTC结构，CTC和血液成分之间的多种相互作用可能促进或阻碍下一个转移步骤-远处部位的外渗.全面了解这些因素如何影响CTC的变形和死亡，可以作为未来实验和模拟的基础。使研究人员能够更准确地预测CTC死亡。最终,这些努力可以导致未来改进的转移特异性治疗和诊断特异性.
