Abstract：
PDGF receptors play pivotal roles in both developmental and physiological processes through the regulation of mesenchymal cells involved in paracrine instructive interactions with epithelial or endothelial cells. Tumor biology studies, alongside analyses of patient tissue samples, provide strong indications that the PDGF signaling pathways are also critical in various types of human cancer. This review summarizes experimental findings and correlative studies, which have explored the biological mechanisms and clinical relevance of PDGFRs in mesenchymal cells of the tumor microenvironment. Collectively, these studies support the overall concept that the PDGF system is a critical regulator of tumor growth, metastasis, and drug efficacy, suggesting yet unexploited targeting opportunities. The inter-patient variability in stromal PDGFR expression, as being linked to prognosis and treatment responses, not only indicates the need for stratified approaches in upcoming therapeutic investigations but also implies the potential for the development of PDGFRs as biomarkers of clinical utility, interestingly also in settings outside PDGFR-directed treatments.
摘要：
PDGF受体通过调节参与与上皮细胞或内皮细胞的旁分泌指导性相互作用的间充质细胞在发育和生理过程中起关键作用。肿瘤生物学研究，除了对患者组织样本的分析，这提供了有力的指示，表明PDGF信号通路在各种类型的人类癌症中也是至关重要的。这篇综述总结了实验结果和相关研究，探讨了肿瘤微环境间充质细胞中PDGFRs的生物学机制和临床意义。总的来说，这些研究支持PDGF系统是肿瘤生长的关键调节因子的总体概念，转移,和药物功效，建议尚未开发的目标机会。基质PDGFR表达的患者间变异性，与预后和治疗反应有关，不仅表明在即将进行的治疗研究中需要分层方法，而且还暗示了开发PDGFRs作为临床效用生物标志物的潜力，有趣的是，在PDGFR指导治疗之外的环境中也是如此。
