Abstract：
OBJECTIVE: To study the analgesic effects and side effects of a transdermal lappaconitine (TLA) patch, ibuprofen suspension (IS), and TLA combined with IS (TLACIS) after adenoidectomy and tonsillectomy.
METHODS: Prospective, randomized clinical trial.
METHODS: The patients were randomized into three groups defined by different analgesic drug regimens: the TLA group, the IS group, and the TLACIS group. Pain scores at 2, 12, and 24 hours after surgery and adverse-event reports within the first postoperative week were collected.
RESULTS: Ultimately, this study included 102 cases in the TLA group, 101 cases in the IS group, and 101 cases in the TLACIS group. At 2 hours after surgery, the pain scores of the TLA and the TLACIS groups were both significantly lower than that of the IS group (all P < .05). At 12 and 24 hours after surgery, the pain score of the TLACIS group was significantly lower than those of the TLA and IS groups (all P < .05); furthermore, the pain score of the IS group was significantly lower than that of the TLA group (P < .05). Within 1 week after the operation, there was no significant difference in the incidence of adverse events.
CONCLUSIONS: The addition of a TLA patch can speed the onset of analgesia. In terms of analgesic effects, IS alone is more advantageous than TLA alone, while the combination of TLA and IS has the best analgesic effect. No significant differences were found in the incidence of adverse events among the three regimens.
METHODS: Prospective, randomized clinical trial.
METHODS: The patients were randomized into three groups defined by different analgesic drug regimens: the TLA group, the IS group, and the TLACIS group. Pain scores at 2, 12, and 24 hours after surgery and adverse-event reports within the first postoperative week were collected.
RESULTS: Ultimately, this study included 102 cases in the TLA group, 101 cases in the IS group, and 101 cases in the TLACIS group. At 2 hours after surgery, the pain scores of the TLA and the TLACIS groups were both significantly lower than that of the IS group (all P < .05). At 12 and 24 hours after surgery, the pain score of the TLACIS group was significantly lower than those of the TLA and IS groups (all P < .05); furthermore, the pain score of the IS group was significantly lower than that of the TLA group (P < .05). Within 1 week after the operation, there was no significant difference in the incidence of adverse events.
CONCLUSIONS: The addition of a TLA patch can speed the onset of analgesia. In terms of analgesic effects, IS alone is more advantageous than TLA alone, while the combination of TLA and IS has the best analgesic effect. No significant differences were found in the incidence of adverse events among the three regimens.
摘要：
目的：为了研究高乌甲素（TLA）透皮贴剂的镇痛作用和副作用，布洛芬混悬液（IS），腺样体切除术和扁桃体切除术后TLA联合IS（TLACIS）。
方法：前瞻性，随机临床试验。
方法：根据不同的镇痛药物方案，将患者随机分为三组：TLA组，IS组,和TLACIS组。收集术后2、12和24小时的疼痛评分以及术后第一周内的不良事件报告。
结果：最终，这项研究包括TLA组102例，IS组101例，TLACIS组101例。手术后2小时，TLA和TLACIS组的疼痛评分均明显低于IS组（均P<0.05）。手术后12和24小时，TLACIS组的疼痛评分明显低于TLA和IS组(均P<0.05);IS组疼痛评分明显低于TLA组（P<0.05）。手术后1周内,不良事件发生率无显著差异.
结论：添加TLA贴片可以加速镇痛的开始。在镇痛作用方面，单独IS比单独TLA更有利，而TLA和IS的联合镇痛效果最好。三种方案的不良事件发生率无显著差异。
方法：前瞻性，随机临床试验。
方法：根据不同的镇痛药物方案，将患者随机分为三组：TLA组，IS组,和TLACIS组。收集术后2、12和24小时的疼痛评分以及术后第一周内的不良事件报告。
结果：最终，这项研究包括TLA组102例，IS组101例，TLACIS组101例。手术后2小时，TLA和TLACIS组的疼痛评分均明显低于IS组（均P<0.05）。手术后12和24小时，TLACIS组的疼痛评分明显低于TLA和IS组(均P<0.05);IS组疼痛评分明显低于TLA组（P<0.05）。手术后1周内,不良事件发生率无显著差异.
结论：添加TLA贴片可以加速镇痛的开始。在镇痛作用方面，单独IS比单独TLA更有利，而TLA和IS的联合镇痛效果最好。三种方案的不良事件发生率无显著差异。
