PDF(Pubmed)
Abstract：
Alzheimer\'s disease (AD) is a progressive neurodegenerative disorder in which changes in hearing sensitivity precede cognitive decline. Despite a well-known link between dementia and hearing loss, few AD model mouse lines have hearing characterized. We screened for hearing loss using auditory brainstem responses (ABR) in young (3-4 months) and aging (9-10 months) mice with a P301S tauopathy (PS19 mice). Compared to wild types, aging PS19 mice did not show accelerated hearing loss but did show latency differences in centrally generated ABR waveform components. These results suggest that tauopathy causes mild central auditory dysfunction in the absence of overt hearing loss.
摘要：
阿尔茨海默病（AD）是一种进行性神经退行性疾病，其中听力敏感性的变化先于认知功能下降。尽管痴呆症和听力损失之间存在着众所周知的联系，少数AD模型小鼠行具有听力特征。我们使用听觉脑干反应（ABR）筛查了患有P301Stau蛋白病的年轻（3-4个月）和衰老（9-10个月）小鼠（PS19小鼠）的听力损失。与野生型相比,老化的PS19小鼠没有表现出加速的听力损失,但在中央产生的ABR波形分量中表现出潜伏期差异.这些结果表明，在没有明显听力损失的情况下，tau蛋白病会导致轻度的中枢听觉功能障碍。
