Abstract：
Background: Coronary artery disease (CAD) is a top life-threatening disease and early and sensitive detection of CAD remains a challenge. This study aimed to assess the value of three-dimensional speckle tracking imaging (3D-STI) in diagnosing CAD patients and investigate the parameters of 3D-STI associated with disease severity. Methods: A total of 260 suspected CAD patients who met the study criteria underwent coronary angiography within one week after the ultrasound examination. Based on the examination results, 142 patients were confirmed to have CAD (CAD group), while 118 patients were classified as non-CAD (NCAD group). Age, gender, family history, smoking status, diabetes, hypertension, dyslipidemia, electrocardiogram, BMI, heart rate, and left ventricular ejection fraction were compared between the two groups. Additionally, 3D-STI parameters including left ventricular global radial strain (GRS), left ventricular global longitudinal strain (GLS), left ventricular global area strain (GAS), and left ventricular global circumferential strain (GCS) were analyzed. Results: No significant differences were found between the CAD and NCAD groups in terms of demographics, smoking history, physiological measurements, and common comorbidities such as diabetes mellitus and dyslipidemia. However, when comparing the 3D-STI parameters, all four parameters, including GLS, GRS, GCS, and GAS, were significantly different in the CAD group compared to the NCAD group. The results suggest that 3D-STI parameters have diagnostic value for CAD, and their changes are associated with CAD severity. Conclusions: Combined detection of these parameters enhances diagnostic accuracy compared to individual detection.
摘要：
背景：冠状动脉疾病（CAD）是一种威胁生命的疾病，早期和灵敏地检测CAD仍然是一个挑战。本研究旨在评估三维斑点追踪成像（3D-STI）在诊断CAD患者中的价值，并研究与疾病严重程度相关的3D-STI参数。方法：共260例符合研究标准的疑似CAD患者在超声检查后一周内接受冠状动脉造影检查。根据检查结果,142例患者被证实患有CAD（CAD组），而118例患者被归类为非CAD（NCAD组）。年龄,性别,家族史,吸烟状况,糖尿病,高血压,血脂异常,心电图,BMI,心率,比较两组患者的左室射血分数。此外,3D-STI参数，包括左心室整体径向应变（GRS），左心室整体纵向应变（GLS），左心室全区应变（GAS），分析左心室整体周向应变（GCS）。结果：在人口统计学方面，CAD和NCAD组之间没有发现显着差异，吸烟史,生理测量，和常见的合并症，如糖尿病和血脂异常。然而,当比较3D-STI参数时，所有四个参数，包括GLS,GRS,GCS,和气体,与NCAD组相比，CAD组有显著差异。结果表明，3D-STI参数对CAD具有诊断价值，它们的变化与CAD严重程度有关。结论：与单独检测相比，这些参数的联合检测可提高诊断准确性。
