关键词: Human inbreeding consanguinity fertility impairment longevity

Mesh : Humans Sweden / epidemiology Longevity Male Fertility Consanguinity Female Adult Middle Aged Inbreeding

来  源:   DOI:10.1080/03014460.2024.2369281

Abstract:
UNASSIGNED: Inbreeding, arising from consanguinity between related parents, has been observed to impact the health of individuals, typically attributed to biological factors. Nevertheless, these effects may be influenced by the social and environmental conditions. The prevalence of consanguineous marriages increased in certain parts of Sweden after it became legal in 1844, which offers a unique opportunity to study and understand the effects of inbreeding on health.
UNASSIGNED: The objective of this study is to explore the potential impact of inbreeding on the longevity, fertility, and impairments of individuals born in the Skellefteå region, Sweden, between 1890 and 1905, with a follow-up period extending until 1950.
UNASSIGNED: The level of inbreeding is calculated using micro-level parish register data and related to longevity, fertility, and impairments using regression analysis.
UNASSIGNED: Inbreeding is shown to be associated with longevity, fertility, and impairments. It seems to affect the risk of stillbirth and impairments and male longevity and fertility.
UNASSIGNED: Inbreeding seems to have had a detrimental effect on some health outcomes in this historical population under study.
摘要:
近亲繁殖,源于相关父母之间的血缘关系,已经观察到影响个人的健康,通常归因于生物因素。然而,这些影响可能受到社会和环境条件的影响。在1844年合法化后,瑞典某些地区近亲结婚的患病率有所增加,这为研究和了解近亲繁殖对健康的影响提供了独特的机会。
这项研究的目的是探索近亲繁殖对长寿的潜在影响,生育力,以及出生在骷髅地区的个体的损伤,瑞典,在1890年至1905年之间,随访期一直持续到1950年。
近亲繁殖的水平是使用微观水平的教区登记数据计算的,与寿命有关,生育力,和使用回归分析的减值。
近亲繁殖与长寿有关,生育力,和损伤。它似乎会影响死产和损伤的风险以及男性的寿命和生育能力。
近亲繁殖似乎对这个历史研究人群的某些健康结果产生了不利影响。
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