Abstract：
Hot melt extrusion by a co-rotating twin screw extruder is an important process in the pharmaceutical industry. Especially for quality by design aspects, a comprehensive process understanding is indispensable. The performance of conveying elements was determined as critical process parameter, and therefore an experimental and numerical framework was developed to analyze and compare variations. A test rig capable of measuring volume flow, pressure and torque with high accuracy and precision was designed and built. The 3D simulation was performed using computational fluid dynamics (CFD). A stationary model with impulse transmission and an apparent motion of the screws was applied. The experimental data were fitted to the model of Pawlowski, and parameters for the pressure (A1, A2) and power characteristics (B1, B2) were determined. Good agreement between experimental data and the model was observed. The simulation was significantly faster compared to common methods, and the results were consistent with the literature. Systematic investigations of a native and worn screw were performed with CFD resulting in a transport capacity increase and a pressure build up decrease for all tested screw elements. An experimental and simulation setup was generated to assess the performance of co-rotating twin screw elements. The experiments provided high-quality data, and the simulations exhibited high flexibility with low computational effort.
摘要：
通过同向旋转双螺杆挤出机的热熔挤出是制药工业中的重要工艺。特别是设计方面的质量，全面的过程理解是必不可少的。输送元件的性能被确定为关键工艺参数，因此，开发了一个实验和数值框架来分析和比较变化。一种能够测量体积流量的试验台，设计和制造了高精度和高精度的压力和扭矩。使用计算流体动力学(CFD)进行3D模拟。应用了具有脉冲传输和螺钉明显运动的固定模型。实验数据与Pawlowski模型拟合，和参数的压力（A1，A2）和功率特性（B1，B2）被确定。观察到实验数据与模型之间的良好一致性。与普通方法相比，模拟速度明显更快，结果与文献一致。使用CFD对天然和磨损的螺钉进行了系统研究，导致所有测试螺钉元件的运输能力增加和压力累积降低。产生实验和模拟装置以评估同向旋转双螺杆元件的性能。实验提供了高质量的数据,模拟显示出高灵活性和低计算量。
