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Abstract：
UNASSIGNED: Yeo\'s Index, product of the mitral leaflet separation index and dimensionless index, is a novel measure of the severity of rheumatic mitral stenosis (MS). We assess Yeo\'s index in patients with rheumatic MS with or without mixed valve disease.
UNASSIGNED: In a retrospective cohort study, Yeo\'s index was measured in 237 cases of rheumatic MS - 124 in a transthoracic echocardiography validation cohort using mitral valve area (MVA) by pressure half-time and planimetry as comparator and 113 in a transesophageal echocardiography (TEE) validation cohort using TEE three-dimensional MVA as comparator. Patients were considered to have mixed valve disease if they had MS and concomitant mitral regurgitation or aortic valve disease.
UNASSIGNED: There were 113 patients with isolated MS and 124 patients with mixed valve disease. Overall, Yeo\'s index ≤ 0.26 cm showed 93.0 % sensitivity and 87.5 % specificity for identifying severe MS (MVA ≤ 1.5 cm2). In isolated MS, Yeo\'s index ≤ 0.26 cm showed sensitivity of 94.6 % and specificity of 90.0 % for identifying severe MS, while in mixed valve disease sensitivity was 90.6 % and specificity 86.7 %. Overall, Yeo\'s index ≤ 0.15 cm showed 83.6 % sensitivity and 94.3 % specificity for very severe MS (MVA ≤ 1.0 cm2). In isolated MS, the threshold of ≤0.15 cm showed sensitivity of 84.4 % and specificity of 92.6 % for very severe MS, while in mixed valve disease sensitivity was 81.3 % and specificity 95.3 %. The presence of atrial fibrillation did not influence the performance of Yeo\'s index.
UNASSIGNED: Yeo\'s Index accurately differentiates severity of rheumatic MS with or without mixed valve disease.
UNASSIGNED: In a retrospective cohort study, Yeo\'s index was measured in 237 cases of rheumatic MS - 124 in a transthoracic echocardiography validation cohort using mitral valve area (MVA) by pressure half-time and planimetry as comparator and 113 in a transesophageal echocardiography (TEE) validation cohort using TEE three-dimensional MVA as comparator. Patients were considered to have mixed valve disease if they had MS and concomitant mitral regurgitation or aortic valve disease.
UNASSIGNED: There were 113 patients with isolated MS and 124 patients with mixed valve disease. Overall, Yeo\'s index ≤ 0.26 cm showed 93.0 % sensitivity and 87.5 % specificity for identifying severe MS (MVA ≤ 1.5 cm2). In isolated MS, Yeo\'s index ≤ 0.26 cm showed sensitivity of 94.6 % and specificity of 90.0 % for identifying severe MS, while in mixed valve disease sensitivity was 90.6 % and specificity 86.7 %. Overall, Yeo\'s index ≤ 0.15 cm showed 83.6 % sensitivity and 94.3 % specificity for very severe MS (MVA ≤ 1.0 cm2). In isolated MS, the threshold of ≤0.15 cm showed sensitivity of 84.4 % and specificity of 92.6 % for very severe MS, while in mixed valve disease sensitivity was 81.3 % and specificity 95.3 %. The presence of atrial fibrillation did not influence the performance of Yeo\'s index.
UNASSIGNED: Yeo\'s Index accurately differentiates severity of rheumatic MS with or without mixed valve disease.
摘要：
■Yeo的索引，二尖瓣小叶分离指数和无量纲指数的乘积，是风湿性二尖瓣狭窄（MS）严重程度的新指标。我们评估有或没有混合性瓣膜疾病的风湿性MS患者的Yeo指数。
■在一项回顾性队列研究中，Yeo指数是在237例风湿性MS-124例中，在经胸超声心动图验证队列中，使用二尖瓣面积（MVA）通过压力半时间和平面分析法作为比较器，在经食管超声心动图（TEE）验证队列中，使用TEE三维MVA作为比较器，测量113例。如果患者患有MS并伴有二尖瓣返流或主动脉瓣疾病，则认为他们患有混合性瓣膜疾病。
■有113例孤立性MS和124例混合性瓣膜疾病。总的来说,Yeo指数≤0.26cm对重度MS(MVA≤1.5cm2)的鉴别敏感性为93.0%,特异性为87.5%。在孤立的MS中，Yeo指数≤0.26cm对重度MS的鉴别敏感性为94.6%,特异性为90.0%,而在混合性瓣膜疾病中的敏感性为90.6%，特异性为86.7%。总的来说,Yeo指数≤0.15cm对重度MS(MVA≤1.0cm2)的敏感性为83.6%,特异性为94.3%。在孤立的MS中，≤0.15cm的阈值对严重MS的敏感性为84.4%，特异性为92.6%，而在混合性瓣膜疾病中，敏感性为81.3%，特异性为95.3%。房颤的存在并不影响Yeo指数的表现。
■Yeo指数可准确区分风湿性MS伴或不伴混合型瓣膜疾病的严重程度。
■在一项回顾性队列研究中，Yeo指数是在237例风湿性MS-124例中，在经胸超声心动图验证队列中，使用二尖瓣面积（MVA）通过压力半时间和平面分析法作为比较器，在经食管超声心动图（TEE）验证队列中，使用TEE三维MVA作为比较器，测量113例。如果患者患有MS并伴有二尖瓣返流或主动脉瓣疾病，则认为他们患有混合性瓣膜疾病。
■有113例孤立性MS和124例混合性瓣膜疾病。总的来说,Yeo指数≤0.26cm对重度MS(MVA≤1.5cm2)的鉴别敏感性为93.0%,特异性为87.5%。在孤立的MS中，Yeo指数≤0.26cm对重度MS的鉴别敏感性为94.6%,特异性为90.0%,而在混合性瓣膜疾病中的敏感性为90.6%，特异性为86.7%。总的来说,Yeo指数≤0.15cm对重度MS(MVA≤1.0cm2)的敏感性为83.6%,特异性为94.3%。在孤立的MS中，≤0.15cm的阈值对严重MS的敏感性为84.4%，特异性为92.6%，而在混合性瓣膜疾病中，敏感性为81.3%，特异性为95.3%。房颤的存在并不影响Yeo指数的表现。
■Yeo指数可准确区分风湿性MS伴或不伴混合型瓣膜疾病的严重程度。
