PDF(Pubmed)
Abstract：
In recent years, the avian influenza virus has emerged as a significant threat to both human and public health. This study focuses on a patient infected with the H10N3 subtype of avian influenza virus, admitted to the Third People\'s Hospital of Kunming City on March 6, 2024. Metagenomic RNA sequencing and polymerase chain reaction (PCR) analysis were conducted on the patient\'s sputum, confirming the H10N3 infection. The patient presented severe pneumonia symptoms such as fever, expectoration, chest tightness, shortness of breath, and cough. Phylogenetic analysis of the Haemagglutinin (HA) and neuraminidase (NA) genes of the virus showed that the virus was most closely related to a case of human infection with the H10N3 subtype of avian influenza virus found in Zhejiang Province, China. Analysis of amino acid mutation sites identified four mutations potentially hazardous to human health. Consequently, this underscores the importance of continuous and vigilant monitoring of the dynamics surrounding the H10N3 subtype of avian influenza virus, utilizing advanced genomic surveillance techniques.
摘要：
近年来,禽流感病毒已成为对人类和公众健康的重大威胁。本研究集中于一名感染H10N3亚型禽流感病毒的患者，2024年3月6日入住昆明市第三人民医院。对患者的痰液进行宏基因组RNA测序和聚合酶链反应（PCR）分析，确认H10N3感染。病人出现严重的肺炎症状，例如发烧，咳痰,胸闷,呼吸急促,还有咳嗽.对该病毒血凝素(HA)和神经氨酸酶(NA)基因的系统发育分析表明,该病毒与浙江省发现的一例人感染H10N3亚型禽流感病毒的病例关系最为密切,中国。氨基酸突变位点的分析确定了四种对人类健康有潜在危害的突变。因此,这强调了持续和警惕监测H10N3亚型禽流感病毒周围动态的重要性，利用先进的基因组监测技术。
