PDF(Pubmed)
Abstract：
Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells that function at the interface between innate and acquired immunity. MAIT cells recognize vitamin B2-related metabolites produced by microbes, through semi-invariant T cell receptor (TCR) and contribute to protective immunity. These foreign-derived antigens are presented by a monomorphic antigen presenting molecule, MHC class I-related molecule 1 (MR1). MR1 contains a malleable ligand-binding pocket, allowing for the recognition of compounds with various structures. However, interactions between MR1 and self-derived antigens are not fully understood. Recently, bile acid metabolites were identified as host-derived ligands for MAIT cells. In this review, we will highlight recent findings regarding the recognition of self-antigens by MAIT cells.
摘要：
粘膜相关的不变T(MAIT)细胞是在先天免疫和获得性免疫之间的界面起作用的先天样T细胞的主要子集。MAIT细胞识别微生物产生的维生素B2相关代谢产物，通过半不变T细胞受体（TCR），并有助于保护性免疫。这些外来衍生的抗原由单态抗原呈递分子呈递，MHCI类相关分子1(MR1)。MR1包含一个可延展的配体结合口袋，允许识别具有各种结构的化合物。然而,MR1与自身来源的抗原之间的相互作用尚未完全了解。最近,胆汁酸代谢物被鉴定为MAIT细胞的宿主衍生配体。在这次审查中,我们将重点介绍MAIT细胞识别自身抗原的最新发现.
