PDF(Pubmed)
Abstract：
UNASSIGNED: The Hand, Foot and Mouth Disease (HFMD), caused by enterovirus 71 infection, is a global public health emergency. Severe HFMD poses a significant threat to the life and well-being of children. Numerous studies have indicated that the occurrence of severe HFMD is associated with cytokine storm. However, the precise molecular mechanism underlying cytokine storm development remains elusive, and there are currently no safe and effective treatments available for severe HFMD in children.
UNASSIGNED: In this study, we established a mouse model of severe HFMD to investigate the molecular mechanisms driving cytokine storm. We specifically analyzed metabolic disturbances, focusing on arginine/ornithine metabolism, and assessed the potential therapeutic effects of spermine, an ornithine metabolite.
UNASSIGNED: Our results identified disturbances in arginine/ornithine metabolism as a pivotal factor driving cytokine storm onset in severe HFMD cases. Additionally, we discovered that spermine effectively mitigated the inflammatory injury phenotype observed in mice with severe HFMD.
UNASSIGNED: In conclusion, our findings provide novel insights into the molecular mechanisms underlying severe HFMD from a metabolic perspective while offering a promising new strategy for its safe and effective treatment.
UNASSIGNED: In this study, we established a mouse model of severe HFMD to investigate the molecular mechanisms driving cytokine storm. We specifically analyzed metabolic disturbances, focusing on arginine/ornithine metabolism, and assessed the potential therapeutic effects of spermine, an ornithine metabolite.
UNASSIGNED: Our results identified disturbances in arginine/ornithine metabolism as a pivotal factor driving cytokine storm onset in severe HFMD cases. Additionally, we discovered that spermine effectively mitigated the inflammatory injury phenotype observed in mice with severe HFMD.
UNASSIGNED: In conclusion, our findings provide novel insights into the molecular mechanisms underlying severe HFMD from a metabolic perspective while offering a promising new strategy for its safe and effective treatment.
摘要：
■手,口蹄疫(HFMD)由肠道病毒71型感染引起，是全球突发公共卫生事件。严重的手足口病对儿童的生命和福祉构成重大威胁。大量研究表明，重症手足口病的发生与细胞因子风暴有关。然而,细胞因子风暴发展的确切分子机制仍然难以捉摸，目前尚无安全有效的治疗儿童重症手足口病的方法。
■在这项研究中，我们建立了重症HFMD小鼠模型，以研究驱动细胞因子风暴的分子机制。我们专门分析了代谢紊乱，专注于精氨酸/鸟氨酸代谢，并评估了精胺的潜在治疗效果，鸟氨酸代谢产物.
■我们的研究结果确定精氨酸/鸟氨酸代谢紊乱是严重HFMD病例中驱动细胞因子风暴发作的关键因素。此外,我们发现精胺可有效缓解重度HFMD小鼠的炎性损伤表型.
■总而言之，我们的研究结果从代谢角度为重症手足口病的分子机制提供了新的见解,同时为其安全有效的治疗提供了有希望的新策略.
■在这项研究中，我们建立了重症HFMD小鼠模型，以研究驱动细胞因子风暴的分子机制。我们专门分析了代谢紊乱，专注于精氨酸/鸟氨酸代谢，并评估了精胺的潜在治疗效果，鸟氨酸代谢产物.
■我们的研究结果确定精氨酸/鸟氨酸代谢紊乱是严重HFMD病例中驱动细胞因子风暴发作的关键因素。此外,我们发现精胺可有效缓解重度HFMD小鼠的炎性损伤表型.
■总而言之，我们的研究结果从代谢角度为重症手足口病的分子机制提供了新的见解,同时为其安全有效的治疗提供了有希望的新策略.
