PDF(Pubmed)
Abstract：
UNASSIGNED: Functional neurological disorder (FND) is a heterogeneous condition; severe forms can be disabling. Multidisciplinary treatment and rehabilitation are recommended for severe FND, but there remains a lack of evidence for its efficacy and lack of understanding of the predictors and components of recovery.
UNASSIGNED: We report clinical outcome data for an inpatient cohort with severe FND. Clinical Global Impression Improvement with treatment is the primary outcome measure. Admission and discharge measures (Euroqol quality of life measures, Beck Depression Inventory, Spielberger Trait Anxiety Inventory, Cambridge Depersonalisation Scale, Illness Perception Questionnaire (Revised) and Functional Mobility Scale) are reported as secondary outcomes.
UNASSIGNED: We describe an FND cohort (n=52) with chronic illness (mean symptom duration 9.7 years). At admission, there were clinically relevant levels of depression, anxiety and depersonalisation derealisation. At the time of discharge, most (43/52) patients\' global condition had improved. Measures of mobility, depression and quality of life also significantly improved while at discharge, symptoms were experienced as more understandable and less distressing than at admission. An admission measure of patient confidence in treatment was predictive of eventual clinical outcome.
UNASSIGNED: The most frequent outcome of inpatient rehabilitation is global improvement, even when symptoms are chronic and severe, reflected in measurable changes in both physical and psychological functioning. Significant levels of depersonalisation derealisation seen in this patient group suggest that routine enquiry into such experiences could help personalise FND treatment approaches. Patient confidence in treatment is key in determining clinical outcomes.
UNASSIGNED: We report clinical outcome data for an inpatient cohort with severe FND. Clinical Global Impression Improvement with treatment is the primary outcome measure. Admission and discharge measures (Euroqol quality of life measures, Beck Depression Inventory, Spielberger Trait Anxiety Inventory, Cambridge Depersonalisation Scale, Illness Perception Questionnaire (Revised) and Functional Mobility Scale) are reported as secondary outcomes.
UNASSIGNED: We describe an FND cohort (n=52) with chronic illness (mean symptom duration 9.7 years). At admission, there were clinically relevant levels of depression, anxiety and depersonalisation derealisation. At the time of discharge, most (43/52) patients\' global condition had improved. Measures of mobility, depression and quality of life also significantly improved while at discharge, symptoms were experienced as more understandable and less distressing than at admission. An admission measure of patient confidence in treatment was predictive of eventual clinical outcome.
UNASSIGNED: The most frequent outcome of inpatient rehabilitation is global improvement, even when symptoms are chronic and severe, reflected in measurable changes in both physical and psychological functioning. Significant levels of depersonalisation derealisation seen in this patient group suggest that routine enquiry into such experiences could help personalise FND treatment approaches. Patient confidence in treatment is key in determining clinical outcomes.
摘要：
■功能性神经障碍（FND）是一种异质性疾病；严重的形式可能是致残的。对于严重的FND，建议多学科治疗和康复，但目前仍缺乏关于其疗效的证据,也缺乏对预后因素和恢复因素的了解.
■我们报告了严重FND住院患者队列的临床结果数据。临床总体印象改善与治疗是主要的结果指标。入院和出院措施(Euroqol生活质量措施，贝克抑郁量表，Spielberger特质焦虑量表，剑桥去个性化量表，疾病感知问卷（修订版）和功能流动性量表）报告为次要结果。
■我们描述了一个患有慢性病（平均症状持续时间9.7年）的FND队列（n=52）。入院时,有临床相关的抑郁水平，焦虑和人格解体。在出院时，大多数（43/52）患者的整体状况有所改善。流动性的措施，出院时抑郁和生活质量也有显著改善，与入院时相比，症状更容易理解，更少痛苦。患者对治疗的信心的入院测量可以预测最终的临床结果。
■住院康复最常见的结果是全球改善，即使症状是慢性和严重的，反映在身体和心理功能的可测量变化。在该患者组中看到的人格解体程度显着表明，对此类经历的常规询问可以帮助个性化FND治疗方法。患者对治疗的信心是确定临床结果的关键。
■我们报告了严重FND住院患者队列的临床结果数据。临床总体印象改善与治疗是主要的结果指标。入院和出院措施(Euroqol生活质量措施，贝克抑郁量表，Spielberger特质焦虑量表，剑桥去个性化量表，疾病感知问卷（修订版）和功能流动性量表）报告为次要结果。
■我们描述了一个患有慢性病（平均症状持续时间9.7年）的FND队列（n=52）。入院时,有临床相关的抑郁水平，焦虑和人格解体。在出院时，大多数（43/52）患者的整体状况有所改善。流动性的措施，出院时抑郁和生活质量也有显著改善，与入院时相比，症状更容易理解，更少痛苦。患者对治疗的信心的入院测量可以预测最终的临床结果。
■住院康复最常见的结果是全球改善，即使症状是慢性和严重的，反映在身体和心理功能的可测量变化。在该患者组中看到的人格解体程度显着表明，对此类经历的常规询问可以帮助个性化FND治疗方法。患者对治疗的信心是确定临床结果的关键。
