PDF(Pubmed)
Abstract：
UNASSIGNED: Anorexia nervosa (AN) is a complex neuropsychiatric disorder. This systematic review synthesizes evidence from diverse studies to assess and investigate the association between gene polymorphisms and psychological and neurobiological factors in patients with AN.
UNASSIGNED: A systematic search across PubMed, PsycINFO, Scopus, and Web of Science databases, along with manual searching, was conducted. The review protocol was approved by PROSPERO (CRD42023452548). Out of 1,250 articles, 11 met the inclusion criteria. The quality of eligible articles was assessed using the Newcastle-Ottawa Scale (NOS) tool. The systematic review followed the PRISMA guidelines.
UNASSIGNED: The serotoninergic system, particularly the 5-HTTLPR polymorphism, is consistently linked to altered connectivity in the ventral attention network, impaired inhibitory control, and increased susceptibility to AN. The 5-HTTLPR polymorphism affects reward processing, motivation, reasoning, working memory, inhibition, and outcome prediction in patients with AN. The dopaminergic system, involving genes like COMT, DRD2, DRD3, and DAT1, regulates reward, motivation, and decision-making. Genetic variations in these dopaminergic genes are associated with psychological manifestations and clinical severity in patients with AN. Across populations, the Val66Met polymorphism in the BDNF gene influences personality traits, eating behaviors, and emotional responses. Genes like OXTR, TFAP2B, and KCTD15 are linked to social cognition, emotional processing, body image concerns, and personality dimensions in patients with AN.
UNASSIGNED: There was an association linking multiple genes to the susceptibly and/or severity of AN. This genetic factor contributes to the complexity of AN and leads to higher diversity of its clinical presentation. Therefore, conducting more extensive research to elucidate the underlying mechanisms of anorexia nervosa pathology is imperative for advancing our understanding and potentially developing targeted therapeutic interventions for the disorder.Systematic review registration: [https://clinicaltrials.gov/], identifier [CRD42023452548].
UNASSIGNED: A systematic search across PubMed, PsycINFO, Scopus, and Web of Science databases, along with manual searching, was conducted. The review protocol was approved by PROSPERO (CRD42023452548). Out of 1,250 articles, 11 met the inclusion criteria. The quality of eligible articles was assessed using the Newcastle-Ottawa Scale (NOS) tool. The systematic review followed the PRISMA guidelines.
UNASSIGNED: The serotoninergic system, particularly the 5-HTTLPR polymorphism, is consistently linked to altered connectivity in the ventral attention network, impaired inhibitory control, and increased susceptibility to AN. The 5-HTTLPR polymorphism affects reward processing, motivation, reasoning, working memory, inhibition, and outcome prediction in patients with AN. The dopaminergic system, involving genes like COMT, DRD2, DRD3, and DAT1, regulates reward, motivation, and decision-making. Genetic variations in these dopaminergic genes are associated with psychological manifestations and clinical severity in patients with AN. Across populations, the Val66Met polymorphism in the BDNF gene influences personality traits, eating behaviors, and emotional responses. Genes like OXTR, TFAP2B, and KCTD15 are linked to social cognition, emotional processing, body image concerns, and personality dimensions in patients with AN.
UNASSIGNED: There was an association linking multiple genes to the susceptibly and/or severity of AN. This genetic factor contributes to the complexity of AN and leads to higher diversity of its clinical presentation. Therefore, conducting more extensive research to elucidate the underlying mechanisms of anorexia nervosa pathology is imperative for advancing our understanding and potentially developing targeted therapeutic interventions for the disorder.Systematic review registration: [https://clinicaltrials.gov/], identifier [CRD42023452548].
摘要：
■神经性厌食症（AN）是一种复杂的神经精神疾病。本系统综述综合了来自各种研究的证据，以评估和研究AN患者的基因多态性与心理和神经生物学因素之间的关联。
■跨PubMed的系统搜索，PsycINFO,Scopus,和WebofScience数据库,随着手动搜索，进行了。审查方案经PROSPERO(CRD42023452548)批准。在1,250篇文章中，11符合纳入标准。使用纽卡斯尔-渥太华量表（NOS）工具评估合格文章的质量。系统审查遵循PRISMA指南。
■5-羟色胺能系统，特别是5-HTTLPR多态性，始终与腹侧注意力网络中改变的连通性相关联，抑制控制受损，对AN的敏感性增加。5-HTTLPR多态性影响奖励处理，动机，推理,工作记忆,抑制,和AN患者的预后预测。多巴胺能系统,涉及像COMT这样的基因，DRD2、DRD3和DAT1调节奖励，动机，和决策。这些多巴胺能基因的遗传变异与AN患者的心理表现和临床严重程度有关。在人群中，BDNF基因的Val66Met多态性影响人格特征，饮食行为,和情绪反应。像OXTR这样的基因,TFAP2B,KCTD15与社会认知有关，情绪处理，身体形象问题，和AN患者的人格维度。
■多个基因与AN的易感和/或严重程度有关联。这种遗传因素有助于AN的复杂性，并导致其临床表现的更高多样性。因此,进行更广泛的研究以阐明神经性厌食症病理的潜在机制对于提高我们的认识和开发针对该疾病的有针对性的治疗干预措施至关重要.系统审查注册：[https://clinicaltrials.gov/]，标识符[CRD42023452548]。
■跨PubMed的系统搜索，PsycINFO,Scopus,和WebofScience数据库,随着手动搜索，进行了。审查方案经PROSPERO(CRD42023452548)批准。在1,250篇文章中，11符合纳入标准。使用纽卡斯尔-渥太华量表（NOS）工具评估合格文章的质量。系统审查遵循PRISMA指南。
■5-羟色胺能系统，特别是5-HTTLPR多态性，始终与腹侧注意力网络中改变的连通性相关联，抑制控制受损，对AN的敏感性增加。5-HTTLPR多态性影响奖励处理，动机，推理,工作记忆,抑制,和AN患者的预后预测。多巴胺能系统,涉及像COMT这样的基因，DRD2、DRD3和DAT1调节奖励，动机，和决策。这些多巴胺能基因的遗传变异与AN患者的心理表现和临床严重程度有关。在人群中，BDNF基因的Val66Met多态性影响人格特征，饮食行为,和情绪反应。像OXTR这样的基因,TFAP2B,KCTD15与社会认知有关，情绪处理，身体形象问题，和AN患者的人格维度。
■多个基因与AN的易感和/或严重程度有关联。这种遗传因素有助于AN的复杂性，并导致其临床表现的更高多样性。因此,进行更广泛的研究以阐明神经性厌食症病理的潜在机制对于提高我们的认识和开发针对该疾病的有针对性的治疗干预措施至关重要.系统审查注册：[https://clinicaltrials.gov/]，标识符[CRD42023452548]。
