PDF(Pubmed)
Abstract：
Introduction: The gastrointestinal tract is integral to defending against external contaminants, featuring a complex array of immunological, physical, chemical, and microbial barriers. Mycotoxins, which are toxic metabolites from fungi, are pervasive in both animal feed and human food, presenting substantial health risks. Methods: This review examines the pharmacological, toxicological, and microbiological impacts of natural products on mycotoxicosis, with a particular focus on the gut-x axis. The analysis synthesizes current understanding and explores the role of natural products rich in polysaccharides, polyphenols, flavonoids, and saponins. Results: The review highlights that mycotoxins can disrupt intestinal integrity, alter inflammatory responses, damage the mucus layer, and disturb the bacterial balance. The toxins\' effects are extensive, potentially harming the immune system, liver, kidneys, and skin, and are associated with serious conditions such as cancer, hormonal changes, genetic mutations, bleeding, birth defects, and neurological issues. Natural products have shown potential anticancer, anti-tumor, antioxidant, immunomodulatory, and antitoxic properties. Discussion: The review underscores the emerging therapeutic strategy of targeting gut microbial modulation. It identifies knowledge gaps and suggests future research directions to deepen our understanding of natural products\' role in gut-x axis health and to mitigate the global health impact of mycotoxin-induced diseases.
摘要：
简介：胃肠道是防御外部污染物的组成部分，具有复杂的免疫学阵列，物理，化学,和微生物屏障。霉菌毒素,它们是真菌的有毒代谢产物，在动物饲料和人类食物中都很普遍，带来巨大的健康风险。方法：这篇综述研究了药理学，毒理学,以及天然产物对霉菌毒性的微生物影响，特别关注肠道x轴。该分析综合了当前的理解，并探讨了富含多糖的天然产物的作用，多酚，黄酮类化合物，和皂苷。结果：该综述强调，真菌毒素可以破坏肠道完整性，改变炎症反应，损伤粘液层，扰乱细菌平衡.毒素的影响是广泛的，有可能伤害免疫系统,肝脏,肾脏，和皮肤，并与癌症等严重疾病有关，荷尔蒙的变化,基因突变,出血,出生缺陷,和神经问题。天然产物已显示出潜在的抗癌作用，抗肿瘤，抗氧化剂，免疫调节,和抗毒性能。讨论：该综述强调了针对肠道微生物调节的新兴治疗策略。它确定了知识差距，并提出了未来的研究方向，以加深我们对天然产物在肠道x轴健康中的作用的理解，并减轻霉菌毒素引起的疾病对全球健康的影响。
