PDF(Pubmed)
Abstract：
Cardiovascular diseases (CVD) remain the leading cause of death worldwide and represent a major public health challenge. YiyiFuzi Powder (YYFZ), composed of Coicis semen and Fuzi, is a classical traditional Chinese medicine prescription from the Synopsis of Golden Chamber dating back to the Han Dynasty. Historically, YYFZ has been used to treat various CVD, rooted in Chinese therapeutic principles. Network pharmacology analysis indicated that YYFZ may exhibit direct or indirect effects on mitochondria-endoplasmic reticulum (ER) interactions. This review, focusing on the cardiovascular protective effects of Coicis semen and Fuzi, summarizes the potential mechanisms by which YYFZ acts on mitochondria and the ER. The underlying mechanisms are associated with regulating cardiovascular risk factors (such as blood lipids and glucose), impacting mitochondrial structure and function, modulating ER stress, inhibiting oxidative stress, suppressing inflammatory responses, regulating cellular apoptosis, and maintaining calcium ion balance. The involved pathways include, but were not limited to, upregulating the IGF-1/PI3K/AKT, cAMP/PKA, eNOS/NO/cGMP/SIRT1, SIRT1/PGC-1α, Klotho/SIRT1, OXPHOS/ATP, PPARα/PGC-1α/SIRT3, AMPK/JNK, PTEN/PI3K/AKT, β2-AR/PI3K/AKT, and modified Q cycle signaling pathways. Meanwhile, the MCU, NF-κB, and JAK/STAT signaling pathways were downregulated. The PERK/eIF2α/ATF4/CHOP, PERK/SREBP-1c/FAS, IRE1, PINK1-dependent mitophagy, and AMPK/mTOR signaling pathways were bidirectionally regulated. High-quality experimental studies are needed to further elucidate the underlying mechanisms of YYFZ in CVD treatment.
摘要：
心血管疾病（CVD）仍然是世界范围内的主要死亡原因，并且是主要的公共卫生挑战。益益附子粉（YYFZ），由Coicis精液和附子组成，是汉代《金殿》的经典中药方剂。历史上,YYFZ已用于治疗各种CVD，根植于中国的治疗原则。网络药理学分析表明，YYFZ可能对线粒体-内质网（ER）相互作用表现出直接或间接的影响。这次审查,重点研究了可可精和附子的心血管保护作用，总结了YYFZ作用于线粒体和ER的潜在机制。潜在的机制与调节心血管危险因素（如血脂和葡萄糖）有关，影响线粒体结构和功能，调节ER应力，抑制氧化应激，抑制炎症反应，调节细胞凋亡，维持钙离子平衡。涉及的途径包括，但不仅限于，上调IGF-1/PI3K/AKT，cAMP/PKA,eNOS/NO/cGMP/SIRT1,SIRT1/PGC-1α,Klotho/SIRT1,OXPHOS/ATP,PPARα/PGC-1α/SIRT3,AMPK/JNK,PTEN/PI3K/AKT,β2-AR/PI3K/AKT,和修饰的Q循环信号通路。同时,MCU,NF-κB,JAK/STAT信号通路下调。PERK/eIF2α/ATF4/CHOP,PERK/SREBP-1c/FAS,IRE1，PINK1依赖性线粒体自噬，AMPK/mTOR信号通路受到双向调控。需要高质量的实验研究来进一步阐明YYFZ在CVD治疗中的潜在机制。
