PDF(Pubmed)
Abstract：
Osteosarcoma is a highly aggressive bone tumor primarily affecting children and adolescents. Despite advancements in treatment modalities, the prognosis for osteosarcoma patients remains poor, emphasizing the need for a deeper understanding of its underlying mechanisms. In recent years, the concept of cancer stem cells (CSCs) has emerged as a crucial factor in tumor initiation, progression, and therapy resistance. These specialized subpopulations of cells possess self-renewal capacity, tumorigenic potential, and contribute to tumor heterogeneity. Sox9, a transcription factor known for its critical role in embryonic development and tissue homeostasis, has been implicated in various malignancies, including osteosarcoma. This review aims to summarize the current knowledge regarding the role of Sox9 in CSCs in osteosarcoma and its potential implications as a prognosis and therapeutic target.
摘要：
骨肉瘤是一种高度侵袭性的骨肿瘤，主要影响儿童和青少年。尽管治疗方式有了进步，骨肉瘤患者的预后仍然很差，强调需要更深入地了解其潜在机制。近年来,癌症干细胞（CSC）的概念已成为肿瘤发生的关键因素，programming,和治疗抵抗。这些特化的细胞亚群具有自我更新能力,致瘤潜力，并导致肿瘤异质性。Sox9是一种转录因子，以其在胚胎发育和组织稳态中的关键作用而闻名，与各种恶性肿瘤有牵连，包括骨肉瘤.这篇综述旨在总结目前关于Sox9在骨肉瘤CSC中的作用及其作为预后和治疗靶点的潜在意义的知识。
