PDF(Pubmed)
Abstract：
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition characterized by monoclonal paraprotein production, with IgM and non-IgM variants. While IgM MGUS is often associated with lymphoid neoplasms, non-IgM MGUS can progress to multiple myeloma. Comorbidities include bone mineral density loss and renal complications, such as monoclonal gammopathy of renal significance (MGRS) and peripheral neuropathy. Cardiovascular risks are also elevated. Despite its significance, MGUS often goes undiagnosed due to its asymptomatic nature and overlap with age-related comorbidities. We present a case of IgM MGRS manifesting as rapidly progressive glomerulonephritis, highlighting the diagnostic challenges and clinical implications of MGUS-associated complications.
摘要：
意义不明的单克隆丙种球蛋白病（MGUS）是一种以单克隆副蛋白产生为特征的癌前疾病，IgM和非IgM变体。虽然MGUSIgM通常与淋巴样肿瘤相关，非IgMMGUS可进展为多发性骨髓瘤。合并症包括骨矿物质密度下降和肾脏并发症，如肾意义的单克隆丙种球蛋白病（MGRS）和周围神经病变。心血管风险也升高。尽管意义重大,MGUS通常由于其无症状性质和与年龄相关的合并症重叠而未被诊断。我们介绍了一例IgMMGRS，表现为快速进展性肾小球肾炎，强调MGUS相关并发症的诊断挑战和临床意义。
