PDF(Pubmed)
Abstract：
UNASSIGNED: A newly introduced obesity-related index, the weight-adjusted-waist index (WWI), emerges as a promising predictor of cardiovascular disease (CVD). Given the known synergistic effects of hypertension and obstructive sleep apnea (OSA) on cardiovascular risk, we aimed to explore the relationship between the WWI and CVD risk specifically within this high-risk cohort.
UNASSIGNED: A total of 2265 participants with hypertension and OSA were included in the study. Multivariate Cox regression analysis was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD events. The restricted cubic spline (RCS) was used to further evaluate the nonlinear dose-response relationship.
UNASSIGNED: During a median follow-up period of 6.8 years, 324 participants experienced a CVD event. Multivariate Cox regression analysis revealed that compared to the reference group, the HRs for the second, third, and fourth groups were 1.12 (95% CI, 0.79-1.59), 1.35 (95% CI, 0.96-1.89), and 1.58 (95% CI, 1.13-2.22), respectively. Moreover, RCS analysis illustrated a clear J-shaped relationship between the WWI and CVD risk, particularly notable when WWI exceeded 11.5 cm/√kg, signifying a significant increase in CVD risk.
UNASSIGNED: There was a J-shaped relationship between WWI and CVD in hypertensive patients with OSA, especially when the WWI was greater than 11.5 cm/√kg, the risk of CVD was significantly increased.
UNASSIGNED: A total of 2265 participants with hypertension and OSA were included in the study. Multivariate Cox regression analysis was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD events. The restricted cubic spline (RCS) was used to further evaluate the nonlinear dose-response relationship.
UNASSIGNED: During a median follow-up period of 6.8 years, 324 participants experienced a CVD event. Multivariate Cox regression analysis revealed that compared to the reference group, the HRs for the second, third, and fourth groups were 1.12 (95% CI, 0.79-1.59), 1.35 (95% CI, 0.96-1.89), and 1.58 (95% CI, 1.13-2.22), respectively. Moreover, RCS analysis illustrated a clear J-shaped relationship between the WWI and CVD risk, particularly notable when WWI exceeded 11.5 cm/√kg, signifying a significant increase in CVD risk.
UNASSIGNED: There was a J-shaped relationship between WWI and CVD in hypertensive patients with OSA, especially when the WWI was greater than 11.5 cm/√kg, the risk of CVD was significantly increased.
摘要：
■一项新引入的肥胖相关指数，体重调整腰围指数(WWI)，作为心血管疾病（CVD）的一个有希望的预测因子。鉴于已知高血压和阻塞性睡眠呼吸暂停（OSA）对心血管风险的协同作用，我们旨在探讨WWI与CVD风险之间的关系,特别是在这一高风险队列中.
■共有2265名患有高血压和OSA的参与者被纳入研究。多变量Cox回归分析用于计算CVD事件的风险比(HRs)和95%置信区间(CIs)。受限三次样条（RCS）用于进一步评估非线性剂量-反应关系。
■在6.8年的中位随访期间，324名参与者经历了CVD事件。多因素Cox回归分析显示，与参照组相比，第二个HR，第三,第四组为1.12（95%CI，0.79-1.59），1.35（95%CI，0.96-1.89），和1.58（95%CI，1.13-2.22），分别。此外，RCS分析表明，WWI与CVD风险之间存在明显的J形关系，特别值得注意的是，当WWI超过11.5厘米/√千克时，表明CVD风险显著增加。
■在OSA的高血压患者中，WWI与CVD之间存在J形关系，特别是当第一次世界大战大于11.5厘米/√公斤时，CVD的风险显著增加.
■共有2265名患有高血压和OSA的参与者被纳入研究。多变量Cox回归分析用于计算CVD事件的风险比(HRs)和95%置信区间(CIs)。受限三次样条（RCS）用于进一步评估非线性剂量-反应关系。
■在6.8年的中位随访期间，324名参与者经历了CVD事件。多因素Cox回归分析显示，与参照组相比，第二个HR，第三,第四组为1.12（95%CI，0.79-1.59），1.35（95%CI，0.96-1.89），和1.58（95%CI，1.13-2.22），分别。此外，RCS分析表明，WWI与CVD风险之间存在明显的J形关系，特别值得注意的是，当WWI超过11.5厘米/√千克时，表明CVD风险显著增加。
■在OSA的高血压患者中，WWI与CVD之间存在J形关系，特别是当第一次世界大战大于11.5厘米/√公斤时，CVD的风险显著增加.
