UNASSIGNED: A total of 2265 participants with hypertension and OSA were included in the study. Multivariate Cox regression analysis was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD events. The restricted cubic spline (RCS) was used to further evaluate the nonlinear dose-response relationship.
UNASSIGNED: During a median follow-up period of 6.8 years, 324 participants experienced a CVD event. Multivariate Cox regression analysis revealed that compared to the reference group, the HRs for the second, third, and fourth groups were 1.12 (95% CI, 0.79-1.59), 1.35 (95% CI, 0.96-1.89), and 1.58 (95% CI, 1.13-2.22), respectively. Moreover, RCS analysis illustrated a clear J-shaped relationship between the WWI and CVD risk, particularly notable when WWI exceeded 11.5 cm/√kg, signifying a significant increase in CVD risk.
UNASSIGNED: There was a J-shaped relationship between WWI and CVD in hypertensive patients with OSA, especially when the WWI was greater than 11.5 cm/√kg, the risk of CVD was significantly increased.
■共有2265名患有高血压和OSA的参与者被纳入研究。多变量Cox回归分析用于计算CVD事件的风险比(HRs)和95%置信区间(CIs)。受限三次样条(RCS)用于进一步评估非线性剂量-反应关系。
■在6.8年的中位随访期间,324名参与者经历了CVD事件。多因素Cox回归分析显示,与参照组相比,第二个HR,第三,第四组为1.12(95%CI,0.79-1.59),1.35(95%CI,0.96-1.89),和1.58(95%CI,1.13-2.22),分别。此外,RCS分析表明,WWI与CVD风险之间存在明显的J形关系,特别值得注意的是,当WWI超过11.5厘米/√千克时,表明CVD风险显著增加。
■在OSA的高血压患者中,WWI与CVD之间存在J形关系,特别是当第一次世界大战大于11.5厘米/√公斤时,CVD的风险显著增加.