PDF(Pubmed)
Abstract：
More than 619 million people in the world suffer from low back pain (LBP). As two potential inducers of LBP, intervertebral disc degeneration (IVDD) and fat infiltration of paraspinal muscles (PSMs) have attracted extensive attention in recent years. So far, only one review has been presented to summarize their relationship and relevant mechanisms. Nevertheless, it has several noticeable drawbacks, such as incomplete categorization and discussion, lack of practical proposals, etc. Consequently, this paper aims to systematically summarize and classify the interaction between IVDD and fat infiltration of PSMs, thus providing a one-stop search handbook for future studies. As a result, four mechanisms of IVDD leading to fat infiltration of PSMs and three mechanisms of fat infiltration in PSMs causing IVDD are thoroughly analyzed and summarized. The typical reseaches are tabulated and evaluated from four aspects, i.e., methods, conclusions, benefits, and drawbacks. We find that IVDD and fat infiltration of PSMs is a vicious cycle that can promote the occurrence and development of each other, ultimately leading to LBP and disability. Finally, eight perspectives are proposed for future in-depth research.
摘要：
世界上有超过6.19亿人患有腰痛（LBP）。作为LBP的两个潜在诱导剂，近年来，椎间盘退变（IVDD）和椎旁肌脂肪浸润（PSMs）引起了广泛的关注。到目前为止,仅提出了一项审查，以总结它们的关系和相关机制。然而，它有几个明显的缺点，如不完整的分类和讨论，缺乏切实可行的建议，等。因此,本文旨在系统总结和分类IVDD与PSM的脂肪浸润之间的相互作用，从而为未来的研究提供了一站式的搜索手册。因此,全面分析和总结了IVDD导致PSM脂肪浸润的四种机制和PSM脂肪浸润导致IVDD的三种机制。从四个方面对典型研究进行了列表和评估，即，方法,结论,好处,和缺点。我们发现IVDD和PSM的脂肪浸润是一个恶性循环，可以促进彼此的发生和发展，最终导致LBP和残疾。最后,提出了未来深入研究的八个观点。
