PDF(Pubmed)
Abstract：
Osseointegration implant (OI) surgery is the latest rehabilitation technology for amputees, where a bone-anchored implant obviates the limitations of traditional socket prostheses. The bone mineral density (BMD) in the periprosthetic and other anatomical regions can be used to assess bone remodelling following OI surgery. Currently, limited studies have used BMD measurements in reporting post-operative OI outcomes and the association between the maintenance of BMD and implant efficacy has remained elusive. This review captured and analysed all studies that have reported the BMD as an objective outcome measure in patients with trans-femoral or trans-tibial OI. The PubMed, Medline, Scopus and Web of Science databases were searched using the terms \'amputation\', \'osseointegration\' and \'bone mineral density\'. A total of 6 studies involving human participants were included for analysis. All studies used dual X-ray absorptiometry and/or X-rays for measuring BMD. Rehabilitation of trans-femoral or trans-tibial amputation using OI may help restore healthy BMD by enabling physiological bone loading. However, there is a low correlation between the BMD around the OI and the success of OI surgery or the risk of periprosthetic fractures. This review summarises the current evidence on BMD assessment in OI for lower limb amputee rehabilitation. Despite the great variability in the results, the available evidence suggests that OI may help restore BMD following surgery. The limited evidence calls for further investigation, as well as the development of a standard BMD measurement protocol.
摘要：
骨整合植入（OI）手术是截肢者的最新康复技术，骨锚式植入物消除了传统接受腔假体的局限性。假体周围和其他解剖区域中的骨矿物质密度（BMD）可用于评估OI手术后的骨重塑。目前,有限的研究将BMD测量值用于报告术后OI结局,而BMD的维持与植入物疗效之间的关联仍然难以捉摸.这篇综述收集并分析了所有报道BMD作为经股或经胫骨OI患者客观结局指标的研究。PubMed,Medline,使用术语“截肢”搜索Scopus和WebofScience数据库，骨整合和骨矿物质密度。总共包括6项涉及人类参与者的研究用于分析。所有研究均使用双重X射线吸收法和/或X射线测量BMD。使用OI的经股或经胫骨截肢的康复可以通过实现生理骨负荷来帮助恢复健康的BMD。然而,OI周围的BMD与OI手术的成功或假体周围骨折的风险之间的相关性较低。这篇综述总结了OI中BMD评估下肢截肢者康复的最新证据。尽管结果差异很大，现有证据表明OI可能有助于手术后恢复BMD.有限的证据需要进一步调查，以及标准BMD测量协议的开发。
