UNASSIGNED: Rat model, pentylenetetrazole (PTZ), an anticonvulsant drug, was selected for the present study. Induction of epilepsy/convulsions was induced by an intraperitoneal injection of PTZ (60 mg/kg body weight) in saline. Biochemical assays performed through spectrophotometer.
UNASSIGNED: Glutamine and Glutamine synthetase levels were decreased in the epileptic rats brain regions i.e., hippocampus, cerebellum, cerebral cortex, and pons medulla; glutamate dehydrogenase and glutaminase levels were increased in all the regions of epilepsy induced rats. Highest values are recorded in hippocampus when compared to other brain regions.
UNASSIGNED: PTZ suppresses the function of Glutamine and Glutamine synthetase activities in selected brain regions of rat and enhances the activities of the glutaminase and glutamate dehydrogenase when compared to control rats.
■大鼠模型,戊四唑(PTZ),抗惊厥药物,被选入本研究。通过腹膜内注射含PTZ(60mg/kg体重)的盐水诱导癫痫/惊厥。通过分光光度计进行生化测定。
■癫痫大鼠脑区的谷氨酰胺和谷氨酰胺合成酶水平降低,即海马体,小脑,大脑皮层,和脑桥延髓;谷氨酸脱氢酶和谷氨酰胺酶水平在癫痫诱发大鼠的所有区域均升高。当与其他脑区域相比时,在海马中记录到最高值。
■与对照大鼠相比,PTZ抑制大鼠选定脑区域中谷氨酰胺和谷氨酰胺合成酶活性的功能,并增强谷氨酰胺酶和谷氨酸脱氢酶的活性。