PDF(Pubmed)
Abstract：
BACKGROUND: CaIMR is proposed as a novel angiographic index designed to assess microcirculation without the need for pressure wires or hyperemic agents. We aimed to investigate the impact of caIMR on predicting clinical outcomes in STEMI patients.
METHODS: One hundred and forty patients with STEMI who received PCI in Putuo Hospital of Shanghai from October 2021 to September 2022 were categorized into CMD and non-CMD groups according to the caIMR value. The baseline information, patient-related examinations, and the occurrence of MACE at the 12-month follow-up were collected to investigate risk factors in patients with STEMI.
RESULTS: We divided 140 patients with STEMI enrolled into two groups according to caIMR results, including 61 patients diagnosed with CMD and 79 patients diagnosed with non-CMD. A total of 21 MACE occurred during the 1 year of follow-up. Compared with non-CMD group, patients with CMD showed a significantly higher risk of MACE. A multivariate Cox regression model was conducted for the patients, and it was found thatcaIMR was a significant predictor of prognosis in STEMI patients (HR: 8.921). Patients with CMD were divided into culprit vascular CMD and non-culprit vascular CMD, and the result found that culprit vascular CMD was associated with the incidence of MACE (OR: 4.75) and heart failure (OR: 7.50).
CONCLUSIONS: CaIMR is a strong predictor of clinical outcomes and can provide an objective risk stratification for patients with STEMI. There is a strong correlation among leukocyte index, the use of furosemide, Killips classification, and clinical outcomes.
METHODS: One hundred and forty patients with STEMI who received PCI in Putuo Hospital of Shanghai from October 2021 to September 2022 were categorized into CMD and non-CMD groups according to the caIMR value. The baseline information, patient-related examinations, and the occurrence of MACE at the 12-month follow-up were collected to investigate risk factors in patients with STEMI.
RESULTS: We divided 140 patients with STEMI enrolled into two groups according to caIMR results, including 61 patients diagnosed with CMD and 79 patients diagnosed with non-CMD. A total of 21 MACE occurred during the 1 year of follow-up. Compared with non-CMD group, patients with CMD showed a significantly higher risk of MACE. A multivariate Cox regression model was conducted for the patients, and it was found thatcaIMR was a significant predictor of prognosis in STEMI patients (HR: 8.921). Patients with CMD were divided into culprit vascular CMD and non-culprit vascular CMD, and the result found that culprit vascular CMD was associated with the incidence of MACE (OR: 4.75) and heart failure (OR: 7.50).
CONCLUSIONS: CaIMR is a strong predictor of clinical outcomes and can provide an objective risk stratification for patients with STEMI. There is a strong correlation among leukocyte index, the use of furosemide, Killips classification, and clinical outcomes.
摘要：
背景：CaIMR被提出作为一种新颖的血管造影指标，旨在评估微循环，而无需压力线或充血剂。我们旨在探讨caIMR对预测STEMI患者临床结局的影响。
方法：根据caIMR值将2021年10月至2022年9月在上海市普陀医院行PCI的150例STEMI患者分为CMD组和非CMD组。基线信息，与病人相关的检查,收集随访12个月时MACE的发生情况，探讨STEMI患者的危险因素。
结果：我们根据caIMR结果将140例STEMI患者分为两组，包括61例诊断为CMD的患者和79例诊断为非CMD的患者。随访1年期间共发生21次MACE。与非CMD组相比，CMD患者出现MACE的风险显著增高.对患者进行多变量Cox回归模型，发现caIMR是STEMI患者预后的重要预测因子（HR：8.921）。将CMD患者分为罪犯血管CMD和非罪犯血管CMD，结果发现，罪犯血管CMD与MACE（OR：4.75）和心力衰竭（OR：7.50）的发生率有关。
结论：CaIMR是临床结局的强预测因子，可以为STEMI患者提供客观的风险分层。白细胞指数之间有很强的相关性，使用呋塞米，Killips分类,和临床结果。
方法：根据caIMR值将2021年10月至2022年9月在上海市普陀医院行PCI的150例STEMI患者分为CMD组和非CMD组。基线信息，与病人相关的检查,收集随访12个月时MACE的发生情况，探讨STEMI患者的危险因素。
结果：我们根据caIMR结果将140例STEMI患者分为两组，包括61例诊断为CMD的患者和79例诊断为非CMD的患者。随访1年期间共发生21次MACE。与非CMD组相比，CMD患者出现MACE的风险显著增高.对患者进行多变量Cox回归模型，发现caIMR是STEMI患者预后的重要预测因子（HR：8.921）。将CMD患者分为罪犯血管CMD和非罪犯血管CMD，结果发现，罪犯血管CMD与MACE（OR：4.75）和心力衰竭（OR：7.50）的发生率有关。
结论：CaIMR是临床结局的强预测因子，可以为STEMI患者提供客观的风险分层。白细胞指数之间有很强的相关性，使用呋塞米，Killips分类,和临床结果。
