Abstract：
Periodontitis, a prevalent chronic inflammatory disease, poses significant challenges for effective treatment due to its complex etiology involving specific bacteria and the inflammatory immune microenvironment. Here, this study presents a novel approach for the targeted treatment of periodontitis utilizing the immunomodulatory and antibacterial properties of Embelin, a plant-derived compound, within an injectable hydrogel system. The developed Carboxymethyl Chitosan-Oxidized Dextran (CMCS-OD) hydrogel formed via dynamic chemical bonds exhibited self-healing capabilities and pH-responsive behavior, thereby facilitating the controlled release of Embelin and enhancing its efficacy in a dynamic oral periodontitis microenvironment. This study demonstrates that this hydrogel system effectively prevents bacterial invasion and mitigates excessive immune response activation. Moreover, it precisely modulates macrophage M1/M2 phenotypes and suppresses inflammatory cytokine expression, thereby fostering a conducive environment for bone regeneration and addressing periodontitis-induced bone loss. These findings highlight the potential of the approach as a promising strategy for the clinical management of periodontitis-induced bone destruction.
摘要：
牙周炎,一种流行的慢性炎症性疾病，由于其涉及特定细菌和炎症免疫微环境的复杂病因，对有效治疗提出了重大挑战。这里,这项研究提出了一种利用Embelin的免疫调节和抗菌特性靶向治疗牙周炎的新方法，一种植物来源的化合物，在可注射水凝胶系统内。通过动态化学键形成的开发的羧甲基壳聚糖氧化葡聚糖（CMCS-OD）水凝胶表现出自我修复能力和pH响应行为，从而促进Embelin的控制释放并增强其在动态口腔牙周炎微环境中的功效。这项研究表明，这种水凝胶系统有效地防止细菌入侵并减轻过度的免疫反应激活。此外，它精确地调节巨噬细胞M1/M2表型并抑制炎性细胞因子表达，从而促进骨再生和解决牙周炎引起的骨丢失的有利环境。这些发现强调了该方法作为牙周炎引起的骨破坏的临床管理的有希望的策略的潜力。
