Abstract：
People with metabolically healthy obesity (MHO) are at risk of developing cardiometabolic diseases. We investigated the prevalence of MHO and factors influencing its transition into a metabolically unhealthy state (MUS). This study was conducted as part of the Kerman Coronary Artery Disease Risk Factor Study (KERCADRS). From 2014 to 2018, 9997 people were evaluated. The obesity and metabolic status of the MHO participants were re-examined after 5 years of their initial participation in the study. Out of 347 MHO, 238 individuals were accessed at follow-up. Twenty-nine (12.2%) had metabolic unhealthy normal weight (MUNW), 169 (71.0%) had metabolic unhealthy obesity (MUO), and the others had healthy metabolic state. Among age, total cholesterol, diastolic blood pressure and triglyceride (TG) variables, the baseline serum TG level was associated with a significant increase in the risk of developing MUS during 5 years (p <.05). The TG level optimal cut-off point for predicting the development into MUS was 107 mg/dL with 62.1% sensitivity and 77.5% specificity (AUC = 0.734, p <.001). A high percentage of MHO people transit into MUS during 5 years. A TG level higher than 107 mg/dL can help to identify people at a higher risk of developing into MUS.
摘要：
代谢健康肥胖（MHO）的人有患心脏代谢疾病的风险。我们调查了MHO的患病率以及影响其转变为代谢不健康状态（MUS）的因素。这项研究是作为Kerman冠状动脉疾病危险因素研究（KERCADRS）的一部分进行的。从2014年到2018年，评估了9997人。MHO参与者的肥胖和代谢状态在他们最初参与研究5年后被重新检查。在347MHO中，238人在随访中被访问。29人（12.2%）有代谢不健康的正常体重（MUNW），169名（71.0%）患有代谢不健康肥胖（MUO），其他人有健康的代谢状态。年龄,总胆固醇,舒张压和甘油三酯（TG）变量，基线血清TG水平与5年内发生MUS的风险显著增加相关(p<.05)。预测发展为MUS的TG水平最佳切点为107mg/dL，灵敏度为62.1％，特异性为77.5％（AUC=0.734，p<.001）。在5年内，很高比例的MHO人进入MUS。高于107mg/dL的TG水平可以帮助识别发展为MUS的风险较高的人。
