Abstract：
OBJECTIVE: To compare the ocular surface disease index (OSDI) questionnaire with objective tests in dry eye disease.
METHODS: A prospective observational study. Place and Duration of the Study: Department of Ophthalmology, Nigde Omer Halisdemir University, Nigde, Turkiye, from 9th June to 31st December 2022.
METHODS: All clinically diagnosed 323 eyes of patients with dry eye disease (DED) were included. The subjects were evaluated by the Oxford classification of corneal and conjunctival fluorescein staining, Schirmer I test, and fluorescein tear breakup time (TBUT). Symptoms of the patients were interpreted with OSDI and correlations of symptoms and objective markers were analysed.
RESULTS: There was no significant association between any objective signs (Schirmer I, TBUT, and Oxford), and OSDI (p = 0.26, 0.52, 0.18, and respectively). Schirmer I score showed a significant positive correlation with TBUT (p <0.001, r = 0.21) and a significant negative correlation with Oxford scale (p <0.001, r = -0.19). There was a statistically negative correlation between TBUT and Oxford scale (p <0.001, r = -0.37).
CONCLUSIONS: Except for the Schirmer test, TBUT and Oxford scale are effective tools in the diagnosis of DED. Symptom markers, such as OSDI may have lower reliability in diagnosing DED and determining its severity. Diagnostic tests are important in the detection of asymptomatic or less severe dry eye disease that can be ignored.
BACKGROUND: Dry eye disease, Diagnosis, Ocular surface disease index (OSDI), Tear breakup time (TBUT), Oxford grading scale, Schirmer I test.
METHODS: A prospective observational study. Place and Duration of the Study: Department of Ophthalmology, Nigde Omer Halisdemir University, Nigde, Turkiye, from 9th June to 31st December 2022.
METHODS: All clinically diagnosed 323 eyes of patients with dry eye disease (DED) were included. The subjects were evaluated by the Oxford classification of corneal and conjunctival fluorescein staining, Schirmer I test, and fluorescein tear breakup time (TBUT). Symptoms of the patients were interpreted with OSDI and correlations of symptoms and objective markers were analysed.
RESULTS: There was no significant association between any objective signs (Schirmer I, TBUT, and Oxford), and OSDI (p = 0.26, 0.52, 0.18, and respectively). Schirmer I score showed a significant positive correlation with TBUT (p <0.001, r = 0.21) and a significant negative correlation with Oxford scale (p <0.001, r = -0.19). There was a statistically negative correlation between TBUT and Oxford scale (p <0.001, r = -0.37).
CONCLUSIONS: Except for the Schirmer test, TBUT and Oxford scale are effective tools in the diagnosis of DED. Symptom markers, such as OSDI may have lower reliability in diagnosing DED and determining its severity. Diagnostic tests are important in the detection of asymptomatic or less severe dry eye disease that can be ignored.
BACKGROUND: Dry eye disease, Diagnosis, Ocular surface disease index (OSDI), Tear breakup time (TBUT), Oxford grading scale, Schirmer I test.
摘要：
目的：比较眼表疾病指数（OSDI）问卷与干眼症的客观测试。
方法：一项前瞻性观察性研究。研究的地点和持续时间：眼科，NigdeOmerHalisdemir大学,Nigde,Turkiye,2022年6月9日至12月31日。
方法：纳入临床诊断为干眼病（DED）的323只眼。通过角膜和结膜荧光素染色的牛津分类对受试者进行评估，Schirmer我测试，和荧光素撕裂破裂时间(TBUT)。用OSDI解释患者的症状，并分析症状和客观标志物的相关性。
结果：任何客观体征之间都没有显着关联（SchirmerI，TBUT,和牛津），和OSDI(分别为p=0.26、0.52、0.18和)。SchirmerI评分与TBUT呈显著正相关(p<0.001,r=0.21),与牛津量表呈显著负相关(p<0.001,r=-0.19)。TBUT与Oxford量表之间存在统计学负相关(p<0.001,r=-0.37)。
结论：除了Schirmer检验，TBUT和Oxford量表是诊断DED的有效工具。症状标记,例如OSDI在诊断DED和确定其严重程度方面可能具有较低的可靠性。诊断测试对于检测无症状或可忽略的较不严重的干眼症很重要。
背景：干眼症，诊断,眼表疾病指数（OSDI），撕裂破裂时间(TBUT),牛津分级量表，我测试的Schirmer。
方法：一项前瞻性观察性研究。研究的地点和持续时间：眼科，NigdeOmerHalisdemir大学,Nigde,Turkiye,2022年6月9日至12月31日。
方法：纳入临床诊断为干眼病（DED）的323只眼。通过角膜和结膜荧光素染色的牛津分类对受试者进行评估，Schirmer我测试，和荧光素撕裂破裂时间(TBUT)。用OSDI解释患者的症状，并分析症状和客观标志物的相关性。
结果：任何客观体征之间都没有显着关联（SchirmerI，TBUT,和牛津），和OSDI(分别为p=0.26、0.52、0.18和)。SchirmerI评分与TBUT呈显著正相关(p<0.001,r=0.21),与牛津量表呈显著负相关(p<0.001,r=-0.19)。TBUT与Oxford量表之间存在统计学负相关(p<0.001,r=-0.37)。
结论：除了Schirmer检验，TBUT和Oxford量表是诊断DED的有效工具。症状标记,例如OSDI在诊断DED和确定其严重程度方面可能具有较低的可靠性。诊断测试对于检测无症状或可忽略的较不严重的干眼症很重要。
背景：干眼症，诊断,眼表疾病指数（OSDI），撕裂破裂时间(TBUT),牛津分级量表，我测试的Schirmer。
