METHODS: Patients were selected who underwent both radical prostatectomy and preoperative MRI scans. MRI scans provided quantitative measurements of prostatic zone dimensions, while histo-anatomical slides yielded quantitative data on glandular density of the peripheral zone (PZ) using imaging software. Integration of MRI and histopathology enabled the assessment of the GVPZ. Statistical analysis identified relationships between total prostate volume (TPV) and GVPZ.
RESULTS: Seventy-two patients were selected and 40 cc was determined to be the optimal cutoff for small-to-moderate versus large prostates. Once the two subgroups in TPV were formed, the relationship between TPV and GVPZ was found to be highly significant (p<0.001).
CONCLUSIONS: The combination of MRI and histopathology offers a novel approach for precise quantification of glandular tissue within the prostatic PZ. This study corroborates the hypothesis of PZ compression via an enlarging transition zone in larger BPH prostates, resulting in PZ glandular atrophy. Given that most PCa originates in the PZ, these results shed light on the potential protective role of larger BPH prostates against PCa growth.
方法:选择接受前列腺癌根治术和术前MRI扫描的患者。MRI扫描提供了前列腺区尺寸的定量测量,而组织解剖切片使用成像软件获得了外周区(PZ)腺体密度的定量数据。MRI和组织病理学的整合使得能够评估GVPZ。统计分析确定了总前列腺体积(TPV)和GVPZ之间的关系。
结果:选择72例患者,并确定40cc是小至中度前列腺与大前列腺的最佳截止值。一旦TPV中的两个亚组形成,发现TPV和GVPZ之间的关系非常显着(p<0.001)。
结论:MRI和组织病理学的结合为前列腺PZ内腺体组织的精确定量提供了一种新方法。这项研究证实了在较大的BPH前列腺中通过扩大的过渡区进行PZ压缩的假设,导致PZ腺体萎缩。鉴于大多数PCa起源于PZ,这些结果揭示了较大的BPH前列腺对PCa生长的潜在保护作用。