PDF(Pubmed)
Abstract：
Gulf War Illness (GWI) is characterized by a wide range of symptoms that manifests largely as gastrointestinal symptoms. Among these gastrointestinal symptoms, motility disorders are highly prevalent, presenting as chronic constipation, stomach pain, indigestion, diarrhea, and other conditions that severely impact the quality of life of GWI veterans. However, despite a high prevalence of gastrointestinal impairments among these veterans, most research attention has focused on neurological disturbances. This perspective provides a comprehensive overview of current in vivo research advancements elucidating the underlying mechanisms contributing to gastrointestinal disorders in GWI. Generally, these in vivo and in vitro models propose that neuroinflammation alters gut motility and drives the gastrointestinal symptoms reported in GWI. Additionally, this perspective highlights the potential and challenges of in vitro bioengineering models, which could be a crucial contributor to understanding and treating the pathology of gastrointestinal related-GWI.
摘要：
海湾战争疾病（GWI）的特征是广泛的症状，主要表现为胃肠道症状。在这些胃肠道症状中，运动障碍非常普遍，表现为慢性便秘，胃痛,消化不良,腹泻,以及其他严重影响GWI退伍军人生活质量的疾病。然而,尽管这些退伍军人中胃肠道损伤的患病率很高，大多数研究注意力都集中在神经系统疾病上。这一观点提供了当前体内研究进展的全面概述，阐明了GWI中胃肠道疾病的潜在机制。一般来说,这些体内和体外模型表明，神经炎症改变肠道运动，并驱动GWI中报道的胃肠道症状。此外,这种观点突出了体外生物工程模型的潜力和挑战，这可能是理解和治疗胃肠道相关GWI病理的关键因素。
