PDF(Pubmed)
Abstract：
Gestational hypertension (PIH), especially pre-eclampsia (PE), is a common complication of pregnancy. This condition poses significant risks to the health of both the mother and the fetus. Emerging evidence suggests that epigenetic modifications, particularly DNA methylation, may play a role in initiating the earliest pathophysiology of PIH. This article describes the relationship between DNA methylation and placental trophoblast function, genes associated with the placental microenvironment, the placental vascular system, and maternal blood and vascular function, abnormalities of umbilical cord blood and vascular function in the onset and progression of PIH, as well as changes in DNA methylation in the progeny of PIH, in terms of maternal, fetal, and offspring. We also explore the latest research on DNA methylation-based early detection, diagnosis and potential therapeutic strategies for PIH. This will enable the field of DNA methylation research to continue to enhance our understanding of the epigenetic regulation of PIH genes and identify potential therapeutic targets.
摘要：
妊娠期高血压(PIH),尤其是先兆子痫（PE），是怀孕的常见并发症。这种情况对母亲和胎儿的健康都构成重大风险。新出现的证据表明表观遗传修饰，特别是DNA甲基化，可能在启动PIH的最早病理生理学中起作用。本文介绍了DNA甲基化与胎盘滋养细胞功能的关系,与胎盘微环境相关的基因，胎盘血管系统,以及母体血液和血管功能，在PIH的发病和进展中，脐带血和血管功能异常，以及PIH子代DNA甲基化的变化，在母性方面，胎儿,和后代。我们还探索了基于DNA甲基化的早期检测的最新研究，PIH的诊断和潜在治疗策略。这将使DNA甲基化研究领域继续增强我们对PIH基因表观遗传调控的理解并确定潜在的治疗靶标。
