PDF(Pubmed)
Abstract：
Skeletal muscular atrophy is a complex disease involving a large number of gene expression regulatory networks and various biological processes. Despite extensive research on this topic, its underlying mechanisms remain elusive, and effective therapeutic approaches are yet to be established. Recent studies have shown that epigenetics play an important role in regulating skeletal muscle atrophy, influencing the expression of numerous genes associated with this condition through the addition or removal of certain chemical modifications at the molecular level. This review article comprehensively summarizes the different types of modifications to DNA, histones, RNA, and their known regulators. We also discuss how epigenetic modifications change during the process of skeletal muscle atrophy, the molecular mechanisms by which epigenetic regulatory proteins control skeletal muscle atrophy, and assess their translational potential. The role of epigenetics on muscle stem cells is also highlighted. In addition, we propose that alternative splicing interacts with epigenetic mechanisms to regulate skeletal muscle mass, offering a novel perspective that enhances our understanding of epigenetic inheritance\'s role and the regulatory network governing skeletal muscle atrophy. Collectively, advancements in the understanding of epigenetic mechanisms provide invaluable insights into the study of skeletal muscle atrophy. Moreover, this knowledge paves the way for identifying new avenues for the development of more effective therapeutic strategies and pharmaceutical interventions.
摘要：
骨骼肌萎缩是一种复杂的疾病，涉及大量的基因表达调控网络和各种生物学过程。尽管对这个主题进行了广泛的研究，其潜在机制仍然难以捉摸，和有效的治疗方法尚未建立。最近的研究表明，表观遗传学在调节骨骼肌萎缩中起着重要作用。通过在分子水平上添加或去除某些化学修饰来影响与这种情况相关的许多基因的表达。这篇综述文章全面总结了对DNA的不同类型的修饰，组蛋白,RNA,和他们已知的监管机构。我们还讨论了表观遗传修饰在骨骼肌萎缩过程中的变化，表观遗传调节蛋白控制骨骼肌萎缩的分子机制，并评估它们的翻译潜力。还强调了表观遗传学对肌肉干细胞的作用。此外,我们认为可变剪接与表观遗传机制相互作用以调节骨骼肌质量，提供了一个新的视角，增强了我们对表观遗传的作用和控制骨骼肌萎缩的调节网络的理解。总的来说，对表观遗传机制的理解的进步为骨骼肌萎缩的研究提供了宝贵的见解。此外，这些知识为确定开发更有效的治疗策略和药物干预措施的新途径铺平了道路。
