尿石素 A 通过分泌性粘蛋白合成升高介导的肠屏障功能增强。
关键词: AhR signaling Colitis prevention Intestinal barrier function Mucin 2 production Nrf2 pathway Urolithin A
Mesh : Animals NF-E2-Related Factor 2 / metabolism Receptors, Aryl Hydrocarbon / metabolism Mice Intestinal Mucosa / metabolism Coumarins / pharmacology Colitis / metabolism chemically induced Mucin-2 / metabolism genetics Humans Colon / metabolism Mice, Inbred C57BL Signal Transduction / drug effects Male Gastrointestinal Microbiome Mice, Knockout Dextran Sulfate Basic Helix-Loop-Helix Transcription Factors / metabolism genetics Intestinal Barrier Function
来 源:
DOI:10.1038/s41598-024-65791-x
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