拓扑异构酶 2 催化活性的抑制会影响异染色质和重复 DNA 的完整性 , 并导致成簇重复序列之间的互连。
Mesh : DNA Topoisomerases, Type II / metabolism genetics Heterochromatin / metabolism Animals Topoisomerase II Inhibitors / pharmacology Repetitive Sequences, Nucleic Acid / genetics Poly-ADP-Ribose Binding Proteins / metabolism genetics DNA Replication DNA, Superhelical / metabolism chemistry Humans Mice DNA-Binding Proteins / metabolism genetics DNA / metabolism chemistry Interphase
来 源:
DOI:10.1038/s41467-024-49816-7
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