关键词: Drug delivery Lipid nanoparticle Lipid signaling Liposomes Nanostructured lipid carriers Solid lipid nanoparticles

Mesh : Nanoparticles / chemistry Humans Liposomes / chemistry Signal Transduction Lipids / chemistry Animals Drug Delivery Systems / methods Lipid Metabolism

来  源:   DOI:10.1007/978-1-0716-3902-3_5

Abstract:
This chapter provides an overview of the diverse range of applications associated with nanoparticles. The application of nanoparticles in the medical field has garnered considerable attention due to their unique properties and versatile compositions. They have shown promise in the treatment of cancer, fungal and viral infections, and pain management. These systems provide numerous benefits, such as increased drug stability, improved bioavailability, and targeted delivery to specific tissues or cells. The objective of this chapter is to provide a brief analysis of the differences between nanoparticles and lipid particles, focusing particularly on the importance of nanoparticle size and composition in their interactions with lipids. Additionally, the applications of nanoparticles in lipid signaling will be discussed, considering the vital roles lipids play in cellular signaling pathways. Nanoparticles have shown immense potential in the regulation and control of medical pathways. In this case, we will focus on the manufacture of liposomes, a type of nanoparticle composed of lipids. The reason behind the extensive investigation into liposomes as drug delivery vehicles is their remarkable biocompatibility and adaptability. This section will provide insights into the methods and techniques employed for liposome formulation.
摘要:
本章概述了与纳米粒子相关的各种应用。纳米颗粒在医学领域的应用由于其独特的性质和多功能的组成而引起了相当大的关注。他们在治疗癌症方面表现出了希望,真菌和病毒感染,和疼痛管理。这些系统提供了许多好处,例如增加药物稳定性,提高生物利用度,和靶向递送到特定的组织或细胞。本章的目的是简要分析纳米颗粒和脂质颗粒之间的差异,特别关注纳米颗粒大小和组成在它们与脂质相互作用中的重要性。此外,将讨论纳米颗粒在脂质信号中的应用,考虑到脂质在细胞信号通路中的重要作用。纳米颗粒在调节和控制医学途径方面显示出巨大的潜力。在这种情况下,我们将专注于脂质体的制造,一种由脂质组成的纳米颗粒。对脂质体作为药物递送载体的广泛研究背后的原因是它们显著的生物相容性和适应性。本部分将提供对用于脂质体制剂的方法和技术的见解。
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