Abstract：
OBJECTIVE: This study aimed to investigate the hearing outcomes in patients with sudden sensorineural hearing loss without vertigo (SSNHLwoV).
METHODS: Patients with SSNHLwoV managed from December 2016 to March 2020 were prospectively enrolled in an academic tertiary referral center. Fifty-one patients with SSNHLwoV who completed high-dose steroid treatment. The hearing prognosis was analyzed using a multivariate Cox regression model.
RESULTS: The rates of complete, partial, and no hearing recovery were 52.9%, 17.6%, and 29.4% in patients with SSNHLwoV, respectively. The video head impulse test (vHIT) of the posterior semicircular canal (PSC), high-tone hearing loss (4-8 kHz) ≥ 30 dB, and average hearing threshold (0.5-1-2-4 kHz) were significantly associated with incomplete recovery of hearing after treatment. In multivariate analysis, the vHIT of the PSC (hazard ratio [HR], 14.502; 95% confidence interval [CI], 1.371-153.355) and high-tone hearing loss ≥ 30 dB (HR, 9.170; 95% CI, 2.283-36.830) remained robust.
CONCLUSIONS: Abnormal vestibular function tests were performed in 80.4% of the patients with SSNHLwoV. Abnormal vHIT of the PSC and high-tone hearing loss ≥ 30 dB were independent factors resulting in incomplete recovery of hearing in patients with SSNHLwoV. In the SSNHLwoV cohort, the caloric test was not significantly associated with hearing prognosis, and vHIT was a feasible predictor of treatment outcome.
METHODS: Patients with SSNHLwoV managed from December 2016 to March 2020 were prospectively enrolled in an academic tertiary referral center. Fifty-one patients with SSNHLwoV who completed high-dose steroid treatment. The hearing prognosis was analyzed using a multivariate Cox regression model.
RESULTS: The rates of complete, partial, and no hearing recovery were 52.9%, 17.6%, and 29.4% in patients with SSNHLwoV, respectively. The video head impulse test (vHIT) of the posterior semicircular canal (PSC), high-tone hearing loss (4-8 kHz) ≥ 30 dB, and average hearing threshold (0.5-1-2-4 kHz) were significantly associated with incomplete recovery of hearing after treatment. In multivariate analysis, the vHIT of the PSC (hazard ratio [HR], 14.502; 95% confidence interval [CI], 1.371-153.355) and high-tone hearing loss ≥ 30 dB (HR, 9.170; 95% CI, 2.283-36.830) remained robust.
CONCLUSIONS: Abnormal vestibular function tests were performed in 80.4% of the patients with SSNHLwoV. Abnormal vHIT of the PSC and high-tone hearing loss ≥ 30 dB were independent factors resulting in incomplete recovery of hearing in patients with SSNHLwoV. In the SSNHLwoV cohort, the caloric test was not significantly associated with hearing prognosis, and vHIT was a feasible predictor of treatment outcome.
摘要：
目的：本研究旨在调查无眩晕突发性感觉神经性听力损失（SSNHLwoV）患者的听力结果。
方法：从2016年12月至2020年3月接受治疗的SSNHLwoV患者被前瞻性纳入一个学术三级转诊中心。51例SSNHLwoV患者完成了高剂量类固醇治疗。使用多变量Cox回归模型分析听力预后。
结果：完成率，局部,听力恢复率为52.9%,17.6%,和29.4%的SSNHLwoV患者，分别。后半规管（PSC）的视频头脉冲测试（vHIT），高音听力损失（4-8kHz）≥30dB，平均听力阈值（0.5-1-2-4kHz）与治疗后听力的不完全恢复显着相关。在多变量分析中，PSC的vHIT(危险比[HR]，14.502；95%置信区间[CI]，1.371-153.355）和高音听力损失≥30dB（HR，9.170；95%CI，2.283-36.830）保持稳健。
结论：80.4%的SSNHLwoV患者进行了异常前庭功能测试。PSCvHIT异常和高音听力损失≥30dB是导致SSNHLwoV患者听力恢复不全的独立因素。在SSNHLwoV队列中，热量测试与听力预后没有显着相关，vHIT是治疗结果的可行预测因子。
方法：从2016年12月至2020年3月接受治疗的SSNHLwoV患者被前瞻性纳入一个学术三级转诊中心。51例SSNHLwoV患者完成了高剂量类固醇治疗。使用多变量Cox回归模型分析听力预后。
结果：完成率，局部,听力恢复率为52.9%,17.6%,和29.4%的SSNHLwoV患者，分别。后半规管（PSC）的视频头脉冲测试（vHIT），高音听力损失（4-8kHz）≥30dB，平均听力阈值（0.5-1-2-4kHz）与治疗后听力的不完全恢复显着相关。在多变量分析中，PSC的vHIT(危险比[HR]，14.502；95%置信区间[CI]，1.371-153.355）和高音听力损失≥30dB（HR，9.170；95%CI，2.283-36.830）保持稳健。
结论：80.4%的SSNHLwoV患者进行了异常前庭功能测试。PSCvHIT异常和高音听力损失≥30dB是导致SSNHLwoV患者听力恢复不全的独立因素。在SSNHLwoV队列中，热量测试与听力预后没有显着相关，vHIT是治疗结果的可行预测因子。
