Abstract：
Cancer metabolism is now a key area for therapeutic intervention, targeting unique metabolic reprogramming crucial for tumor growth and survival. This article reviews the therapeutic potential of addressing metabolic vulnerabilities through glycolysis and glutaminase inhibitors, which disrupt cancer cell metabolism. Challenges such as tumor heterogeneity and adaptive resistance are discussed, with strategies including personalized medicine and predictive biomarkers to enhance treatment efficacy. Additionally, integrating diet and lifestyle changes with metabolic targeting underscores a holistic approach to improving therapy outcomes. The article also examines the benefits of incorporating these strategies into standard care, highlighting the potential for more tailored, safer treatments. In conclusion, exploiting metabolic vulnerabilities promises a new era in oncology, positioning metabolic targeting at the forefront of personalized cancer therapy and transforming patient care.
摘要：
癌症代谢现在是治疗干预的关键领域，靶向独特的代谢重编程对于肿瘤生长和存活至关重要。本文回顾了通过糖酵解和谷氨酰胺酶抑制剂解决代谢脆弱性的治疗潜力，破坏癌细胞的新陈代谢.讨论了肿瘤异质性和适应性抗性等挑战，采用包括个性化医疗和预测生物标志物在内的策略来提高治疗效果。此外,将饮食和生活方式的改变与代谢靶向相结合,强调了改善治疗结果的整体方法.本文还研究了将这些策略纳入标准护理的好处，强调更有可能量身定制，更安全的治疗方法总之,利用代谢漏洞预示着肿瘤学的新时代，将代谢靶向定位在个性化癌症治疗和转变患者护理的最前沿。
