Abstract：
In recent decades, there has been a burgeoning interest in cell membrane coating strategies as innovative approach for targeted delivery systems in biomedical applications. Platelet membrane-coated nanoparticles (PNPs), in particular, are gaining interest as a new route for targeted therapy due to their advantages over conventional drug therapies. Their stepwise approach blends the capabilities of the natural platelet membrane (PM) with the adaptable nature of manufactured nanomaterials, resulting in a synergistic combination that enhances drug delivery and enables the development of innovative therapeutics. In this context, we present an overview of the latest advancements in designing PNPs with various structures tailored for precise drug delivery. Initially, we describe the types, preparation methods, delivery mechanisms, and specific advantages of PNPs. Next, we focus on three critical applications of PNPs in diseases: vascular disease therapy, cancer treatment, and management of infectious diseases. This review presents our knowledge of PNPs, summarizes their advancements in targeted therapies and discusses the promising potential for clinical translation of PNPs.
摘要：
近几十年来,作为生物医学应用中靶向递送系统的创新方法，人们对细胞膜涂层策略的兴趣日益浓厚。血小板膜包覆纳米颗粒（PNP），特别是,由于其优于常规药物治疗的优势，作为靶向治疗的新途径越来越受到人们的关注。他们的逐步方法将天然血小板膜（PM）的能力与人造纳米材料的适应性相结合，产生协同组合，增强药物递送并能够开发创新疗法。在这种情况下，我们概述了设计PNP的最新进展，该PNP具有为精确药物输送量身定制的各种结构。最初，我们描述了类型，制备方法,交付机制，以及PNP的特定优势。接下来,我们专注于PNP在疾病中的三个关键应用：血管疾病治疗，癌症治疗,和传染病管理。这篇综述介绍了我们对PNP的了解，总结了他们在靶向治疗方面的进展，并讨论了PNP临床转化的有希望的潜力。
