重组 OC43 SARS - CoV - 2 刺突替代病毒 : 用于 SARS - CoV - 2 中和测定的改进的 BSL - 2 代理病毒。
关键词: HCoV-OC43 SARS-CoV-2 coronavirus mucosal vaccine virus-neutralizing antibodies
Mesh : Animals Spike Glycoprotein, Coronavirus / immunology genetics SARS-CoV-2 / immunology genetics Humans Antibodies, Neutralizing / immunology Mice COVID-19 / immunology virology prevention & control Antibodies, Viral / immunology Neutralization Tests / methods Mice, Transgenic Coronavirus OC43, Human / immunology genetics COVID-19 Vaccines / immunology administration & dosage Angiotensin-Converting Enzyme 2 / metabolism immunology Chlorocebus aethiops Vero Cells Macaca mulatta
来 源:
DOI:10.1073/pnas.2310421121
PDF(Pubmed)