PDF(Pubmed)
Abstract：
Comparative analyses of gene birth-death dynamics have the potential to reveal gene families that played an important role in the evolution of morphological, behavioral, or physiological variation. Here, we used whole genomes of 30 species of butterflies and moths to identify gene birth-death dynamics among the Lepidoptera that are associated with specialist or generalist feeding strategies. Our work advances this field using a uniform set of annotated proteins for all genomes, investigating associations while correcting for phylogeny, and assessing all gene families rather than a priori subsets. We discovered that the sizes of several important gene families (e.g. those associated with pesticide resistance, xenobiotic detoxification, and/or protein digestion) are significantly correlated with diet breadth. We also found 22 gene families showing significant shifts in gene birth-death dynamics at the butterfly (Papilionoidea) crown node, the most notable of which was a family of pheromone receptors that underwent a contraction potentially linked with a shift to visual-based mate recognition. Our findings highlight the importance of uniform annotations, phylogenetic corrections, and unbiased gene family analyses in generating a list of candidate genes that warrant further exploration.
摘要：
基因出生-死亡动力学的比较分析有可能揭示在形态学进化中起重要作用的基因家族，行为，或生理变异。这里,我们使用了30种蝴蝶和飞蛾的全基因组来鉴定与专家或通才喂养策略相关的鳞翅目中的基因出生-死亡动态.我们的工作推进了这一领域，使用了一组统一的所有基因组的注释蛋白质，在纠正系统发育的同时调查关联，并评估所有基因家族而不是先验子集。我们发现几个重要的基因家族的大小（例如与农药抗性相关的基因家族，外源性生物解毒，和/或蛋白质消化）与饮食宽度显着相关。我们还发现22个基因家族在蝴蝶（Papilionoidea）冠状节点的基因出生-死亡动力学中显示出显著的变化，其中最值得注意的是一个信息素受体家族，其收缩可能与基于视觉的伴侣识别转变有关。我们的发现强调了统一注释的重要性，系统发育校正，和无偏见的基因家族分析，以生成需要进一步探索的候选基因列表。
