Abstract：
The greatest challenges that organisms face today are effective responses or detection of life-threatening environmental changes due to an obvious semblance of stress and metabolic fluctuations. These are associated with different pathological conditions among which cancer is most important. Sirtuins (SIRTs; NAD+-dependent enzymes) are versatile enzymes with diverse substrate preferences, cellular locations, crucial for cellular processes and pathological conditions. This article describes in detail the distinct roles of SIRT isoforms, unveiling their potential as either cancer promoters or suppressors and also explores how both natural and synthetic compounds influence the SIRT function, indicating promise for therapeutic applications. We also discussed the inhibitors/activators tailored to specific SIRTs, holding potential for diseases lacking effective treatments. It may uncover the lesser-studied SIRT isoforms (e.g., SIRT6, SIRT7) and their unique functions. This article also offers a comprehensive overview of SIRTs, linking them to a spectrum of diseases and highlighting their potential for targeted therapies, combination approaches, disease management, and personalized medicine. We aim to contribute to a transformative era in healthcare and innovative treatments by unraveling the intricate functions of SIRTs.
摘要：
生物今天面临的最大挑战是有效的反应或检测由于明显的压力和代谢波动而威胁生命的环境变化。这些与不同的病理状况有关，其中癌症是最重要的。Sirtuins(SIRTs;NAD+依赖性酶)是具有不同底物偏好的多功能酶,蜂窝位置，对于细胞过程和病理状况至关重要。本文详细描述了SIRT亚型的不同作用，揭示了它们作为癌症促进剂或抑制剂的潜力，并探讨了天然和合成化合物如何影响SIRT功能，表明治疗应用的希望。我们还讨论了针对特定SIRTs的抑制剂/活化剂，持有缺乏有效治疗的疾病的潜力。它可能会发现研究较少的SIRT同工型(例如，SIRT6、SIRT7)及其独特功能。本文还提供了SIRTs的全面概述，将它们与一系列疾病相关，并突出它们靶向治疗的潜力，组合方法，疾病管理,个性化医疗。我们的目标是通过解开SIRTs的复杂功能，为医疗保健和创新治疗的变革时代做出贡献。
