Abstract：
Microfluidics have been widely used for cell sorting and capture. In this work, numerical simulations of cell transport in microfluidic devices were studied considering cell sizes, deformability, and five different device designs. Among these five designs, deterministic lateral displacement device (DLD) and hyperuniform device (HU) performed better in promoting cell-micropost collision due to the continuously shifted micropost positions as compared with regular grid, staggered, and hexagonal layout designs. However, the grid and the hexagonal layouts showed best in differentiating cells by their size dependent velocity due to the size exclusion effect for cell transport in clear and straight paths in the flow direction. A systematic study of the velocity differentiation under different dimensionless groups was performed showing that the velocity difference is dominated by the micropost separation distance perpendicular to the direction of flow. Microfluidic experiments also confirmed the velocity differentiation results. The study can provide guiding principles for microfluidic design.
摘要：
微流体已经广泛用于细胞分选和捕获。在这项工作中,考虑细胞大小，研究了微流控设备中细胞运输的数值模拟，可变形性,和五种不同的设备设计。＆＃xD;在这五个设计中，确定性横向位移装置（DLD）和超均匀装置（HU）在促进细胞微柱碰撞方面表现更好，因为与规则网格相比，微柱位置连续移动。交错,和六边形布局设计。然而,网格和六边形布局通过其大小依赖性速度在区分细胞方面表现出最佳效果，这归因于在流动方向上清晰而笔直的细胞运输的大小排除效应。对不同无量纲组下的速度差异进行了系统研究，表明速度差由垂直于流动方向的微柱分离距离决定。微流体实验也证实了速度分化的成果。该研究可为微流控设计提供指导原则。
