PDF(Pubmed)
Abstract：
Renal aspergillosis is a rare yet potentially devastating complication following renal allograft transplantation. We present the case of a 45-year-old male with a history of crescentic IgA nephropathy who underwent renal allograft transplantation from his mother. Despite initial favorable progress, he developed post-transplant renal dysfunction attributed to active antibody-mediated rejection. Subsequently, he presented with signs of systemic infection and graft dysfunction, leading to the diagnosis of renal aspergillosis. Despite aggressive management, including antifungal therapy and cessation of immunosuppression, the patient progressed to renal graft cortical necrosis, necessitating nephrectomy. This case underscores the challenges in diagnosing and managing renal aspergillosis in transplant recipients and highlights the importance of early recognition and prompt intervention to improve outcomes in such cases.
摘要：
肾曲霉病是同种异体肾移植后罕见但潜在的破坏性并发症。我们介绍了一名45岁的男性，有新月体IgA肾病病史，他从母亲那里接受了同种异体肾移植。尽管最初取得了有利进展，他出现了由于活性抗体介导的排斥反应导致的移植后肾功能障碍.随后，他表现出全身感染和移植物功能障碍的迹象，导致肾曲霉病的诊断。尽管积极的管理，包括抗真菌治疗和停止免疫抑制，患者进展为移植肾皮质坏死,需要进行肾切除术。该病例强调了移植受者诊断和治疗肾曲霉病的挑战，并强调了早期识别和及时干预以改善此类病例结果的重要性。
