METHODS: RNA sequencing data from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) project, survival data from TCGA, and protein expression data from the Human Protein Atlas were systematically analyzed.
RESULTS: Among the four protein-coding transcripts of BSG, ENST00000353555 encoding basigin-2 is the dominant transcript isoform. It might be an independent prognostic biomarker for unfavorable overall survival in patients with liver cancer (HR: 1.404, 95% CI: 1.1224-1.754, p = 0.003).
CONCLUSIONS: ENST00000353555 might be a prognostic biomarker linking unfavorable overall survival in liver cancer patients.
方法:来自癌症基因组图谱(TCGA)和基因型组织表达(GTEx)项目的RNA测序数据,生存数据来自TCGA,和来自人类蛋白质图谱的蛋白质表达数据进行了系统分析。
结果:在BSG的四种蛋白质编码转录物中,编码basigin-2的ENST00000353555是显性转录物同种型。它可能是肝癌患者不良总生存期的独立预后生物标志物(HR:1.404,95%CI:1.1224-1.754,p=0.003)。
结论:ENST00000353555可能是与肝癌患者不利的总体生存率相关的预后生物标志物。