PDF(Pubmed)
Abstract：
Metabolic syndrome poses a significant health concern, particularly among postmenopausal women who are vulnerable to its adverse effects. Emerging evidence suggests a potential role of vitamin D in mitigating metabolic syndrome risk factors, prompting interest in its supplementation as a therapeutic intervention. This comprehensive review examines the impact of vitamin D supplementation on metabolic syndrome variables in postmenopausal women. Through a systematic synthesis of existing literature, we assess the evidence supporting the beneficial effects of vitamin D on insulin sensitivity, lipid profiles, and inflammation markers in this population. While findings suggest potential benefits, uncertainties remain regarding optimal dosage and duration of supplementation. Implications for clinical practice underscore the importance of assessing vitamin D status and considering supplementation as part of a comprehensive approach to metabolic health management. Furthermore, public health initiatives promoting adequate vitamin D intake may help mitigate the prevalence of metabolic syndrome and associated complications. However, further research is warranted to elucidate the underlying mechanisms, establish optimal supplementation protocols, and explore potential interactions with other nutrients or medications. Long-term randomized controlled trials are needed to evaluate the sustained effects of vitamin D supplementation on metabolic health outcomes in postmenopausal women.
摘要：
代谢综合征引起了严重的健康问题，特别是在绝经后的妇女谁是脆弱的不利影响。新的证据表明，维生素D在缓解代谢综合征危险因素方面具有潜在作用。促使人们对其补充作为治疗干预的兴趣。这篇综合综述研究了补充维生素D对绝经后妇女代谢综合征变量的影响。通过对现有文献的系统综合，我们评估了支持维生素D对胰岛素敏感性有益作用的证据，脂质分布，和这个人群中的炎症标志物。虽然研究结果表明了潜在的好处，关于补充的最佳剂量和持续时间仍然存在不确定性。对临床实践的影响强调了评估维生素D状态和考虑补充维生素D作为代谢健康管理综合方法的一部分的重要性。此外，促进充足维生素D摄入的公共卫生举措可能有助于减轻代谢综合征和相关并发症的患病率.然而,需要进一步的研究来阐明潜在的机制，建立最佳补充方案，并探索与其他营养素或药物的潜在相互作用。需要长期随机对照试验来评估补充维生素D对绝经后妇女代谢健康结果的持续影响。
