PDF(Pubmed)
Abstract：
This case report presents the clinical presentation, diagnosis, and management of a 16-year-old female with elevated cortisol levels who was diagnosed with mania. The patient exhibited symptoms consistent with a manic episode, including extreme euphoria, decreased need for sleep, impulsivity, and heightened irritability. Laboratory investigations revealed an elevated morning cortisol level, prompting further psychiatric evaluation. A diagnosis of bipolar I disorder, manic episode, was made based on established criteria. The patient was initiated on mood stabilizers and antipsychotic medications alongside psychoeducation for the patient and her family. This case underscores the potential association between cortisol dysregulation and mood disorders, highlighting the importance of comprehensive assessment and personalized treatment approaches in adolescents with bipolar disorder. Further research is needed to elucidate the underlying mechanisms linking cortisol dysregulation and mood disturbances and explore novel therapeutic interventions targeting hypothalamic-pituitary-adrenal axis dysfunction.
摘要：
本病例报告介绍了临床表现，诊断,和管理一名16岁女性，皮质醇水平升高，被诊断为躁狂症。患者表现出与躁狂发作一致的症状，包括极度的兴奋,减少对睡眠的需求，冲动,和高度的烦躁。实验室调查显示早晨皮质醇水平升高，促使进一步的精神病学评估。诊断为I型双相情感障碍,躁狂发作,是根据既定标准制定的。患者开始接受情绪稳定剂和抗精神病药物治疗，同时对患者及其家人进行心理教育。这个案例强调了皮质醇失调和情绪障碍之间的潜在关联，强调全面评估和个性化治疗方法在青少年双相情感障碍中的重要性。需要进一步的研究来阐明皮质醇失调和情绪障碍的潜在机制，并探索针对下丘脑-垂体-肾上腺轴功能障碍的新型治疗干预措施。
