PDF(Pubmed)
Abstract：
UNASSIGNED: We conducted a text mining analysis of 40 years of literature on cardiac aging from PubMed to investigate the current understanding on cardiac aging and its mechanisms. This study aimed to embody what most researchers consider cardiac aging to be.
UNASSIGNED: We used multiple text mining and machine learning tools to extract important information from a large amount of text.
UNASSIGNED: Analysis revealed that the terms most frequently associated with cardiac aging include \"diastolic,\" \"hypertrophy,\" \"fibrosis,\" \"apoptosis,\" \"mitochondrial,\" \"oxidative,\" and \"autophagy.\" These terms suggest that cardiac aging is characterized by mitochondrial dysfunction, oxidative stress, and impairment of autophagy, especially mitophagy. We also revealed an increase in the frequency of occurrence of \"autophagy\" in recent years, suggesting that research on autophagy has made a breakthrough in the field of cardiac aging. Additionally, the frequency of occurrence of \"mitophagy\" has increased significantly since 2019, suggesting that mitophagy is an important factor in cardiac aging.
UNASSIGNED: Cardiac aging is a complex process that involves mitochondrial dysfunction, oxidative stress, and impairment of autophagy, especially mitophagy. Further research is warranted to elucidate the mechanisms of cardiac aging and develop strategies to mitigate its detrimental effects.
UNASSIGNED: We used multiple text mining and machine learning tools to extract important information from a large amount of text.
UNASSIGNED: Analysis revealed that the terms most frequently associated with cardiac aging include \"diastolic,\" \"hypertrophy,\" \"fibrosis,\" \"apoptosis,\" \"mitochondrial,\" \"oxidative,\" and \"autophagy.\" These terms suggest that cardiac aging is characterized by mitochondrial dysfunction, oxidative stress, and impairment of autophagy, especially mitophagy. We also revealed an increase in the frequency of occurrence of \"autophagy\" in recent years, suggesting that research on autophagy has made a breakthrough in the field of cardiac aging. Additionally, the frequency of occurrence of \"mitophagy\" has increased significantly since 2019, suggesting that mitophagy is an important factor in cardiac aging.
UNASSIGNED: Cardiac aging is a complex process that involves mitochondrial dysfunction, oxidative stress, and impairment of autophagy, especially mitophagy. Further research is warranted to elucidate the mechanisms of cardiac aging and develop strategies to mitigate its detrimental effects.
摘要：
■我们对PubMed的40年心脏衰老文献进行了文本挖掘分析，以调查当前对心脏衰老及其机制的理解。这项研究旨在体现大多数研究人员认为的心脏衰老。
■我们使用多种文本挖掘和机器学习工具从大量文本中提取重要信息。
■分析表明，与心脏老化最常见的术语包括“舒张”，\"\"肥大,\“\”纤维化，“\”凋亡，“\”线粒体，氧化，\"和\"自噬。“这些术语表明心脏衰老的特征是线粒体功能障碍，氧化应激，和自噬受损，尤其是线粒体自噬.我们还发现近年来“自噬”的发生频率增加，提示自噬的研究在心脏衰老领域取得了突破性进展。此外,自2019年以来，“线粒体自噬”的发生频率显着增加，这表明线粒体自噬是心脏衰老的重要因素。
■心脏衰老是一个复杂的过程，涉及线粒体功能障碍，氧化应激，和自噬受损，尤其是线粒体自噬.需要进一步的研究来阐明心脏衰老的机制，并制定减轻其有害影响的策略。
■我们使用多种文本挖掘和机器学习工具从大量文本中提取重要信息。
■分析表明，与心脏老化最常见的术语包括“舒张”，\"\"肥大,\“\”纤维化，“\”凋亡，“\”线粒体，氧化，\"和\"自噬。“这些术语表明心脏衰老的特征是线粒体功能障碍，氧化应激，和自噬受损，尤其是线粒体自噬.我们还发现近年来“自噬”的发生频率增加，提示自噬的研究在心脏衰老领域取得了突破性进展。此外,自2019年以来，“线粒体自噬”的发生频率显着增加，这表明线粒体自噬是心脏衰老的重要因素。
■心脏衰老是一个复杂的过程，涉及线粒体功能障碍，氧化应激，和自噬受损，尤其是线粒体自噬.需要进一步的研究来阐明心脏衰老的机制，并制定减轻其有害影响的策略。
